Results 101 to 110 of about 1,693,331 (310)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Impact of Environmental Factors on Bacteriocin Promoter Activity in Gut-Derived Lactobacillus salivarius [PDF]

, 2015
peer-reviewedBacteriocin production is regarded as a desirable probiotic trait that aids in colonization and persistence in the gastrointestinal tract (GIT).
Cotter, Paul D., Draper, Lorraine A., Guinane, Caitriona M., Hill, Colin, O'Connor, Paula M., Piper, Clare, Ross, R Paul   +6 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. [PDF]

, 2014
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene ...
Aida K. Dieffenbach, Alexander Hein, Alfons Meindl, Alison M. Dunning, Amanda B. Spurdle, Angel Carracedo, Angela Cox, Angela Jones, Anja Rudolph, Anjali K. Henders, Anne-Lise Børresen-Dale, Annika Lindblom, Anthony J. Swerdlow, Arif B. Ekici, Attila Teoman, Augusto Rojas-Martinez, Bach, Bahcall, Barbara Burwinkel, Berndt, Boris Winterhoff, Brooke L. Fridley, Buchanan, Buchner, Cancer Genome Atlas Research Network, Cancer Genome Atlas Research, N, Carina Walpole, Catherine S. Healey, Cerami, Cuff, Dale R. Nyholt, Deborah J. Thompson, Diether Lambrechts, Douglas F. Easton, Dunham, Edwards, Eeles, Eeles, Eger, Elizabeth Holliday, Ellen L. Goode, Emma Tham, Erika Santos, Felicity A. Lose, Fergus J. Couch, Ferreira, Fiona Bruinsma, Frederic Amant, Frederik Marme, Gao, Garcia-Closas, Garg, Gauderman, Geoffrey Otton, Gerasimos Tzortzatos, Glinsky, Graham G. Giles, Grant W. Montgomery, Grisanzio, Gudmundsson, Harries, Helga B. Salvesen, Henrica M.J. Werner, Hermann Brenner, Higgins, Hiltrud Brauch, Houlston, Howie, Howie, Hughes, Ian Tomlinson, Ingo Runnebaum, Janet E. Olson, Jenny Chang-Claude, Jeroen Depreeuw, Jianjun Liu, Jingmei Li, Jirong Long, Jodie N. Painter, Joe Dennis, John Attia, John L. Hopper, Jonathan P. Tyrer, Jone Trovik, Julian Peto, Julie M. Cunningham, Juliet D. French, Jyotsna Batra, Kaltin Ferguson, Kamila Czene, Katie Ashton, Kimberley Howarth, Kristine M. Hillman, Kyriaki Michailidou, Lazarevich, Leire Moya, Lieve Coenegrachts, Liu, Long, Luis Carvajal-Carmona, Lynn Martin, Ma. Magdalena Echeverry De Polanco, Macintyre, Maggie Gorman, Manjeet K. Bolla, Manuel R. Teixeira, Mark McEvoy, Matthias Dürst, Matthias Ruebner, Matthias W. Beckmann, Matthieu Moisse, McEvoy, McGregor, Melissa C. Southey, Michailidou, Miriam Mints, Mitul Shah, Monica Sans, Nicholas G. Martin, Nicholas Orr, Nicola Johnson, Painter, Pamela Pollock, Paul D.P. Pharoah, Penelope M. Webb, Per Hall, Peter A. Fasching, Peter Hillemanns, Pharoah, Pruim, Qin Wang, Rachel Palmieri Weber, Rodney J. Scott, Sakoda, Sean C. Dowdy, Sergi Castellvi-Bel, Shahana Ahmed, Shao, Shen, Shirley Hodgson, Singh, Spoelstra, Spurdle, Stacey L. Edwards, Stefan P. Renner, Stefanie Schrauwen, Sun, Susanne Kaufmann, Takata, Tavassoli, Teo, Terasawa, Thilo Dörk, Thomas, Timothy Cheng, Tony Proietto, Tormund S. Njolstad, Tracy A. O'Mara, Tsuchiya, Udler, Vessela N. Kristensen, Wei Zheng, Wellcome Trust Case Control Consortium, Xiao-Ou Shu, Yong-Bing Xiang, Zhihua Chen   +165 more
core   +7 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Enhancing Stability of Cu/ZnO Catalysts in the CO₂ Hydrogenation to Methanol by the Addition of MoO₃ and ReO₃ Promoters

Nanomaterials
The catalytic hydrogenation of CO2 to methanol represents a promising route for carbon recycling and hydrogen storage. However, the stability of current catalysts remains one of the main technological challenges.
Jose Soriano Rodríguez, José Manuel López Nieto, Enrique Rodriguez-Castellón, Antonia Infantes, Daviel Gómez, Patricia Concepción   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Retardation of atherosclerosis in immunocompetent apolipoprotein (apo) E-deficient mice followingliver-directed administration of a [E1-, E3-,polymerase-] adenovirus vector containing the elongation factor-1a promoter driving expression of human apoE cDNA [PDF]

, 2005
Although gene transfer of human apolipoprotein E (apoE), a 34-kDa circulating glycoprotein, to the liver of apoEdeficient(apoE-/-) mice using recombinant adenoviral vectors (rAd) is antiatherogenic, its full therapeutic potentialhas yet to be realized ...
Amalfitano, A, Dickson, G, Graham, IR, Harris, JD, Owen, JS, Schepelmann, S, Stannard, AK   +6 more
core  

Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. [PDF]

, 2014
In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene ...
Arriola, David J, Park, Chung Hyun, Rivera, Alissa J, Skarra, Danalea V, Thackray, Varykina G   +4 more
core   +3 more sources