Lentiviral vectors with amplified beta cell-specific gene expression. [PDF]
, 2009 An important goal of gene therapy is to be able to deliver genes, so that they express in a pattern that recapitulates the expression of an endogenous cellular gene.
Crooks, GM +7 more
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The lower bound on the precision of transcriptional regulation [PDF]
, 2014 The diffusive arrival of transcription factors at the promoter sites on the DNA sets a lower bound on how accurately a cell can regulate its protein levels.
Paijmans, Joris, Wolde, Pieter Rein ten
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Promoting human promoters [PDF]
Molecular Systems Biology, 2006 Mol Syst Biol. 2: 2006.0030 The effect of transcription factors on human gene expression can now be quantified owing to a new computational approach. The method was successfully applied to the cases of the cell cycle program, and for liver‐specific gene expression. Transcriptional regulation of gene expression plays a major role in the acquisition of
Furman, Itay, Pilpel, Yitzhak
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Thyroid-specific transcription factors control Hex promoter activity [PDF]
, 2003 The homeobox-containing gene Hex is expressed in several cell types, including thyroid follicular cells, in which it regulates the transcription of tissue-specific genes. In this study the regulation of Hex promoter activity was investigated.
A. V., D'Elia +9 more
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CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]
, 2018 The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad +7 more
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In silico analysis of transcription factor binding sites in promoters of germin-like protein genes in rice [PDF]
Archives of Biological Sciences, 2016 Germins (GERs) and germin-like proteins (GLPs) play important roles in responses to various stresses; however, their function is still not fully understood. Significant insight into their function can be obtained by analyzing their promoters. In
Ilyas Muhammad +2 more
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An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones [PDF]
, 2011 Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Ore reporter mouse system in
Arthur, J. +6 more
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CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]
, 2019 The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad +8 more
core +1 more source
Relationship between promoter sequence and its strength in gene expression
, 2014 In this study, through various tests one theoretical model is presented to describe the relationship between promoter strength and its nucleotide sequence.
Li, Jingwei, Zhang, Yunxin
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Promotion and Evacuation [PDF]
The Electronic Journal of Combinatorics, 2009 Promotion and evacuation are bijections on the set of linear extensions of a finite poset first defined by Schützenberger. This paper surveys the basic properties of these two operations and discusses some generalizations. Linear extensions of a finite poset $P$ may be regarded as maximal chains in the lattice $J(P)$ of order ideals of $P$.
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