Results 41 to 50 of about 1,693,331 (310)

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

A novel constitutive promoter and its downstream 5′ UTR derived from cotton (Gossypium spp.) drive high-level gene expression in stem and leaf tissues

Journal of Integrative Agriculture, 2016
The development of genetically modified crops requires new promoters and regulatory regions to achieve high gene expression and/or tissue-specific expression patterns in plants.
Bao SUN, Guo-qing SUN, Zhi-gang MENG, Rui ZHANG, San-dui GUO   +4 more
doaj   +1 more source

Founder mutation in the PMM2 promotor causes hyperinsulinemic hypoglycaemia/polycystic kidney disease (HIPKD)

Molecular Genetics & Genomic Medicine, 2021
Background Polycystic kidney disease with hyperinsulinaemic hypoglycaemia (HIPKD) is a recently described disease caused by a single nucleotide variant, c.‐167G>T, in the promoter region of PMM2 (encoding phosphomannomutase 2), either in homozygosity or ...
Sumaya Islam, Mehmet Tekman, Sarah E. Flanagan, Lisa Guay‐Woodford, Khalid Hussain, Sian Ellard, Robert Kleta, Detlef Bockenhauer, Horia Stanescu, Daniela Iancu   +9 more
doaj   +1 more source

Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors

Frontiers in Neurology, 2022
Understanding the kinetics and durability of AAV-mediated transgene expression in the brain is essential for conducting basic neuroscience studies as well as for developing gene therapy approaches for CNS diseases.
Bradley S. Hollidge, Hayley B. Carroll, Randolph Qian, Madison L. Fuller, April R. Giles, Andrew C. Mercer, Olivier Danos, Ye Liu, Joseph T. Bruder, Jared B. Smith   +9 more
doaj   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

Myeloid zinc finger 1 (MZF1) is the most important transcriptional factor for porcine follistatin promoter

Journal of Integrative Agriculture, 2015
Follistatin (FS) is a secreted protein, which was originally isolated from porcine follicular fluid. Expression of follistatin is tightly regulated during porcine growth and development.
Ya-meng SUN, Liang WANG, Xiu-qin YANG, Dong-jie ZHANG, Di LIU   +4 more
doaj   +1 more source

Repression of CIITA by the Epstein-Barr virus transcription factor Zta is independent of its dimerization and DNA binding [PDF]

, 2016
Repression of the cellular CIITA gene is part of the immune evasion strategy of the γherpes virus Epstein-Barr virus (EBV) during its lytic replication cycle in B-cells. In part this is mediated through down regulation of MHC class II gene expression via
Adamson, Alison J. Sinclair, Broderick, Crawford, Farrell, Holley-Guthrie, Kay Osborn, Kenney, Kenney, Klug, Mikaélian, Nicolae Balan, Packham, Sinclair, Young   +14 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Isolation and molecular characterization of the FLOWERING LOCUS C gene promoter sequence in radish (Raphanus sativus L.)

Journal of Integrative Agriculture, 2016
Both bolting and flowering times influence taproot and seed production in radish. FLOWERING LOCUS C (FLC) plays a key role in plant flowering by functioning as a repressor.
Yuan-yuan XU, Jing WANG, Shan-shan NIE, Dan-qiong HUANG, Yan WANG, Liang XU, Rong-hua WANG, Xiao-bo LUO, Li-wang LIU   +8 more
doaj   +1 more source

Allelic variants of a potato HEAT SHOCK COGNATE 70 gene confer improved tuber yield under a wide range of environmental conditions

Food and Energy Security, 2023
Previously, we developed and applied a glasshouse screen for potato tuber yield under heat stress and identified a candidate gene (HSc70) for heat tolerance by genetic analysis of a diploid potato population.
Raymond Campbell, Laurence Ducreux, Graham Cowan, Vanessa Young, Gift Chinoko, Gloria Chitedze, Stanley Kwendani, Margaret Chiipanthenga, Craita E. Bita, Obed Mwenye, Hassan Were, Lesley Torrance, Sanjeev Kumar Sharma, Robert D. Hancock, Glenn J. Bryan, Mark Taylor   +15 more
doaj   +1 more source