Results 301 to 310 of about 2,113,360 (356)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Gene mapping and identification of candidate genes controlling carotenoid accumulation of yellow kernels in foxtail millet. [PDF]

BMC Plant Biol
Wang J, Ma Q, Zhang Y, Duan Q, Zhen X, Zhang Y, Li H, Han Y, Zhang B.   +8 more
europepmc   +1 more source

Total synthesis of a tyrosine suppressor transfer RNA gene. XIII. Synthesis of deoxyribopolynucleotide segments corresponding to the nucleotide sequence -1 to -29 in the promoter region.

, 1979
R Belagaje, Eugene L. Brown, Michael J. Gait, H. G. Khorana, Kjeld Norris   +4 more
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A Truncated Endogenous U6 Promoter Enables High-Efficiency CRISPR Editing in Flax (<i>Linum usitatissimum</i> L.). [PDF]

Plants (Basel)
Li F, Xue M, Guo D, Zhu L, Li Y, Xie L.
europepmc   +1 more source

OsERF2 Acts as a Direct Downstream Target of OsEIL1 to Negatively Regulate Salt Tolerance in Rice. [PDF]

Rice (N Y)
Zhou J, Fang S, Liu X, Luo L, Liu Y, Zhang H.   +5 more
europepmc   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

Mouse promoters are characterised by low occupancy and high turnover of RNA polymerase II. [PDF]

Mol Syst Biol
Chatsirisupachai K, Moene CJI, Kleinendorst R, Kreibich E, Molina N, Krebs A.   +5 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Enhancer control of promoter activity and variabilityviafrequency modulation of clustered transcriptional bursts

Tünnermann J, Roth G, Cramard J, Giorgetti L.   +3 more
europepmc   +1 more source