Results 171 to 180 of about 390,492 (308)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping

Brain region- and cell-specific transcriptomic and epigenomic features are associated with heritability for neuropsychiatric traits, but a systematic view, considering cortical and subcortical regions, is lacking.
Scott, William K., Haroutunian, Vahram, Vahram Haroutunian, Dong, Pengfei, Hoffman, Gabriel E., William K. Scott, Nathan Lawless, David A. Davis, Gabriel E. Hoffman, Song, Liting, Liting Song, Bendl, Jaroslav, Shao, Zhiping, Susanne Acker, Davis, David A., John F. Fullard, Edelstien, Jonathan, Panos Roussos, Ruth Misir, Acker, Susanne, Jaroslav Bendl, Zhiping Shao, Roussos, Panos, Jonathan Edelstien, Misir, Ruth, Pengfei Dong, Fullard, John F., Lawless, Nathan   +27 more
core   +1 more source

Seven inducible promoters for Zymomonas mobilis. [PDF]

Microb Cell Fact
Behrendt G.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The <i>Rac1</i> Promoter as a Molecular Nexus for Antihypertensive Therapy Resistance and Enhanced Malaria Susceptibility. [PDF]

Int J Hypertens
Ameke SL, Fosu K, Amenga-Etego L, Sarpong KAN, Kwofie SK.   +4 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Analysis of genetic polymorphism on the promoter region of a human liver carboxylesterase gene

Drug Metabolism and Pharmacokinetics, 1999
HOSOKAWA, Masakiyo, TSUKADA, Eiko, WATANABE, Natsuko, OHHATA, Yoshiko, FUKUMOTO, Maki, MINAMI, Hironobu, FUJII, Hirofumi, SASAKI, Yasutsuna, CHIBA, Kan   +8 more
openaire   +2 more sources

Genome resequencing revealed genetic differentiation and promoter variation in wax secretion genes among geographic populations of Ericerus pela. [PDF]

BMC Genomics
Niu XY, Yang P.
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

The Semantics and Mechanisms of Enhancers and Promoters: "What Is True for <i>E. coli</i> Is True for the Elephant, Only More So". [PDF]

Annu Rev Biochem
Struhl K.
europepmc   +1 more source