Results 191 to 200 of about 593,021 (291)

<i>BRCA1</i> Promoter CpG Methylation in Breast Cancer: A Pilot Study in African Women. [PDF]

Genes (Basel)
Willmer T, Makhetha M, Shaik AR, Mabasa L, Buccimazza I, Aldous C.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pathophysiological Significance of Variants of the HAND1 Gene Promoter in Congenital Atrial Septal Defects: A Study in 632 Chinese Subjects. [PDF]

Hum Mutat
Qi JL, Chen HX, Hou HT, Yang Q, He GW.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. [PDF]

Alzheimers Dement
Ray NR, Kurup J, Kumar A, Rajabli F, Wang L, Xu W, Jin F, Yilmaz E, Kizil C, Bertholim-Nasciben L, Moura S, Ramirez AM, Baiyewu O, Griswold AJ, Coker M, Scott KM, Akinwande K, Adams LD, Diala S, Whitehead PG, McCauley JL, Ogunronbi M, Hamilton-Nelson KL, Damasceno A, Zaman AF, Blanton SH, Akpalu A, Cuccaro ML, Wahab K, McInerney KF, Nuytemans K, Obiako R, Mena PR, Okubadejo N, Martinez IM, Zewde YZ, Gugssa SA, Sarfo FS, Kalaria R, Ndetei DM, Williams SM, Caban-Holt A, ADGC, AfDC, Tosto G, Haines JL, Akinyemi RO, Ogunniyi A, Byrd GS, Bush WS, Kunkle BW, Vance JM, Pericak-Vance MA, Reitz C.   +53 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A Novel Nonsense Variant in TBX15 Transcription Factor Suggests an Expanded Genetic Spectrum Of Submucous Cleft Palate. [PDF]

Int Dent J
Wang Y, Yu K, Huang L, Cheng Y, Fu X, Ji Y.   +5 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Genetic Variation in MMP-1 Promoter Region and

Journal of Sciences, Islamic Republic of Iran, 2008
openaire   +1 more source

Identification of a high-activity and ubiquitous promoter from lepidoptera insect for transgenic applications. [PDF]

J Insect Sci
Bi H, Dong M, Sun Y, Feng C, Xu J.
europepmc   +1 more source