Results 271 to 280 of about 4,748,947 (305)
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Clinics and Research in Hepatology and Gastroenterology, 2020
Genome wide association study has identified chromosome 6p21.33 as a risk locus of hepatocellular carcinoma (HCC). MiR-877 is located on this region, functioning as a tumor suppressor. The aim of this study was to investigate the association between rs1264440 in the promoter of miR-877 and HCC risk.A total of 352 HCC patients and 359 age, gender ...
Hongtu, Wang +3 more
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Genome wide association study has identified chromosome 6p21.33 as a risk locus of hepatocellular carcinoma (HCC). MiR-877 is located on this region, functioning as a tumor suppressor. The aim of this study was to investigate the association between rs1264440 in the promoter of miR-877 and HCC risk.A total of 352 HCC patients and 359 age, gender ...
Hongtu, Wang +3 more
openaire +2 more sources
Molecular Biology Reports, 2010
Leptin is a hormone expressed mainly in white adipose tissue. It acts on satiety centers in the hypothalamus, and by binding to particular receptor OB-Rb, plays a crucial role in controlling appetite, body weight, fat amount and total energy balance. In this study, a novel single nucleotide polymorphism (SNP), i.e., SNP G-2863A, was identified in the ...
Dongjun, Liu +5 more
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Leptin is a hormone expressed mainly in white adipose tissue. It acts on satiety centers in the hypothalamus, and by binding to particular receptor OB-Rb, plays a crucial role in controlling appetite, body weight, fat amount and total energy balance. In this study, a novel single nucleotide polymorphism (SNP), i.e., SNP G-2863A, was identified in the ...
Dongjun, Liu +5 more
openaire +2 more sources
Environmental Toxicology and Pharmacology, 2014
The purpose of this study was to determine the interethnic differences of four CYP1A2 drug metabolizing enzyme variants. A total of 404 Roma and 396 Hungarian healthy subjects were genotyped for -163C>A, -729C>T, -2467delT and -3860G>A variants of CYP1A2 by RT-PCR and PCR-RFLP technique.
Renata, Szalai +7 more
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The purpose of this study was to determine the interethnic differences of four CYP1A2 drug metabolizing enzyme variants. A total of 404 Roma and 396 Hungarian healthy subjects were genotyped for -163C>A, -729C>T, -2467delT and -3860G>A variants of CYP1A2 by RT-PCR and PCR-RFLP technique.
Renata, Szalai +7 more
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A Genetic Variant in the Promoter Region of Toll-Like Receptor 9 and Cervical Cancer Susceptibility
DNA and Cell Biology, 2012The Toll-like receptors (TLRs) are important for the innate immune system by recognizing pathogen-associated molecular patterns expressed in infectious agents. E6 and E7 protein from HPV16 suppress the host immune response by regulating the TLR9 transcript.
Xiaojun, Chen +9 more
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Psychiatry Research, 2017
• Genetic polymorphisms A-21T and C-262T at promoter region of catalase ( CAT ) are functional.
Majede, Rezaei +2 more
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• Genetic polymorphisms A-21T and C-262T at promoter region of catalase ( CAT ) are functional.
Majede, Rezaei +2 more
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Gene, 1993
The nucleotide sequence of the promoter distal region of the major operon associated with biosynthesis of TCP, the toxin coregulated pilus of Vibrio cholerae has been determined. The genes tcpR, tcpD, tcpS, tcpT, tcpE and tcpF are organized to permit translational coupling and are followed by an inverted repeat structure which is likely to act as a ...
M A, Ogierman +3 more
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The nucleotide sequence of the promoter distal region of the major operon associated with biosynthesis of TCP, the toxin coregulated pilus of Vibrio cholerae has been determined. The genes tcpR, tcpD, tcpS, tcpT, tcpE and tcpF are organized to permit translational coupling and are followed by an inverted repeat structure which is likely to act as a ...
M A, Ogierman +3 more
openaire +2 more sources
Gene, 2018
Krüppel-like factor 3 (KLF3), a member of the Krüppel-like factor (KLF) family, plays an important role in adipogenesis and lipid metabolism. The aim of this study was to investigate whether KLF3 could be used as a candidate gene in the breeding of cattle. The expression pattern of bovine KLF3 gene revealed that it was highly expressed in abdominal fat
Hongfang, Guo +11 more
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Krüppel-like factor 3 (KLF3), a member of the Krüppel-like factor (KLF) family, plays an important role in adipogenesis and lipid metabolism. The aim of this study was to investigate whether KLF3 could be used as a candidate gene in the breeding of cattle. The expression pattern of bovine KLF3 gene revealed that it was highly expressed in abdominal fat
Hongfang, Guo +11 more
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BLOOD COAGULATION & FIBRINOLYSIS, 1998
Evidence suggests that an allelic variation in the beta fibrinogen gene may confer an increased risk of coronary artery disease and stroke. The role of the beta fibrinogen gene polymorphism and fibrinogen levels in ischemic stroke has not been determined in Japanese, who are more prone to stroke than to coronary artery disease compared with Caucasians.
S, Nishiuma +8 more
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Evidence suggests that an allelic variation in the beta fibrinogen gene may confer an increased risk of coronary artery disease and stroke. The role of the beta fibrinogen gene polymorphism and fibrinogen levels in ischemic stroke has not been determined in Japanese, who are more prone to stroke than to coronary artery disease compared with Caucasians.
S, Nishiuma +8 more
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Arthritis & Rheumatism, 2001
To determine whether the haplotypes formed on the basis of single-base-exchange polymorphisms at positions -1082, -819, or -592 of the interleukin-10 (IL-10) gene predispose subjects to primary Sjögren's syndrome (SS).The frequency of IL-10 polymorphisms was analyzed in 62 patients with primary SS and in 400 healthy subjects.
J, Hulkkonen +5 more
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To determine whether the haplotypes formed on the basis of single-base-exchange polymorphisms at positions -1082, -819, or -592 of the interleukin-10 (IL-10) gene predispose subjects to primary Sjögren's syndrome (SS).The frequency of IL-10 polymorphisms was analyzed in 62 patients with primary SS and in 400 healthy subjects.
J, Hulkkonen +5 more
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Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2013
The purpose of this study was to discuss the relationship between genetic polymorphism of promoter region let-7 and genetic susceptibility to hepatocellular carcinoma (HCC) in Chinese population.In this case-control study, 1300 cases of HBV positive patients were recruited in case group and another 1344 cases of persistent chronic HBV carriers were ...
Fang, Huang +4 more
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The purpose of this study was to discuss the relationship between genetic polymorphism of promoter region let-7 and genetic susceptibility to hepatocellular carcinoma (HCC) in Chinese population.In this case-control study, 1300 cases of HBV positive patients were recruited in case group and another 1344 cases of persistent chronic HBV carriers were ...
Fang, Huang +4 more
openaire +1 more source