Results 301 to 310 of about 795,608 (343)

Genetic variants in the promoter region of the KLF3 gene associated with fat deposition in Qinchuan cattle

Gene, 2018
Krüppel-like factor 3 (KLF3), a member of the Krüppel-like factor (KLF) family, plays an important role in adipogenesis and lipid metabolism. The aim of this study was to investigate whether KLF3 could be used as a candidate gene in the breeding of cattle. The expression pattern of bovine KLF3 gene revealed that it was highly expressed in abdominal fat
Nicola M. Schreurs, Irfan Ullah, Linsen Zan, Seyed Mahdi Hosseini, Sen Wu, Sayed Haidar Abbas Raza, Song Zhang, Dawei Wei, Li Wang, Le Zhang, Rajwali Khan, Hongfang Guo   +11 more
openaire   +2 more sources

Genetic polymorphisms in promoter and intronic regions of CYP1A2 gene in Roma and Hungarian population samples

Environmental Toxicology and Pharmacology, 2014
The purpose of this study was to determine the interethnic differences of four CYP1A2 drug metabolizing enzyme variants. A total of 404 Roma and 396 Hungarian healthy subjects were genotyped for -163C>A, -729C>T, -2467delT and -3860G>A variants of CYP1A2 by RT-PCR and PCR-RFLP technique.
Erzsebet Kovesdi, Béla Melegh, András Szabó, Zsolt Bánfai, Renata Szalai, Lili Magyari, Balazs Duga, Petra Matyas   +7 more
openaire   +3 more sources

Genetic organization and sequence of the promoter-distal region of the tcp gene cluster of Vibrio cholerae

Gene, 1993
The nucleotide sequence of the promoter distal region of the major operon associated with biosynthesis of TCP, the toxin coregulated pilus of Vibrio cholerae has been determined. The genes tcpR, tcpD, tcpS, tcpT, tcpE and tcpF are organized to permit translational coupling and are followed by an inverted repeat structure which is likely to act as a ...
Susan Zabihi, Paul A. Manning, Monica A. Ogierman, Lefta Mourtzios   +3 more
openaire   +3 more sources

Association between genetic polymorphisms at promoter region of the catalase gene and risk of dependency to heroin

Psychiatry Research, 2017
• Genetic polymorphisms A-21T and C-262T at promoter region of catalase ( CAT ) are functional.
Mostafa Saadat, Majede Rezaei, Mohammad Rashid Khalighinasab   +2 more
openaire   +2 more sources

Genetic variation in the promoter region of the ??-fibrinogen gene is associated with ischemic stroke in a Japanese population

BLOOD COAGULATION & FIBRINOLYSIS, 1998
Evidence suggests that an allelic variation in the beta fibrinogen gene may confer an increased risk of coronary artery disease and stroke. The role of the beta fibrinogen gene polymorphism and fibrinogen levels in ischemic stroke has not been determined in Japanese, who are more prone to stroke than to coronary artery disease compared with Caucasians.
Kazuomi Kario, M. Maeda, Takefumi Matsuo, M. Matsuo, Kazuyuki Shimada, R. Murai, U. Ikeda, K. Yakushijin, Shinichi Nishiuma   +8 more
openaire   +3 more sources

A Genetic Variant Located in miR-146b Promoter Region Is Associated with Prognosis of Gastric Cancer

Cancer Epidemiology, Biomarkers & Prevention, 2018
Abstract Background: SNPs in the promoter region of miRNAs have been reported to be associated with cancer prognosis. Our previous study found that miR-146b had a strong correlation with the stage classification of gastric cancer and contributed to tumor progression.
Mulong Du, Zhipeng Xu, Fengyuan Li, Fulin Qiang, Weida Gong, Bowen Li, Diancai Zhang, Hao Xu, Zekuan Xu, Linjun Wang, Weizhi Wang, Zheng Li, Lei Zhang, Zhengdong Zhang, Qing Li, Li Yang   +15 more
openaire   +3 more sources

Identification and genetic effect of a variable duplication in the promoter region of the cattle ADIPOQ gene

Animal Genetics, 2013
SummaryIn cattle, the ADIPOQ gene is located in the vicinity of the quantitative trait locus (QTL) affecting marbling, the ribeye muscle area and fat thickness on BTA1. In our study, a novel variable duplication (NW_003103812.1:g.9232067_9232133dup) in the bovine ADIPOQ promoter region was identified and genotyped in seven Chinese cattle breeds.
C. L. Zhang, Chuzhao Lei, Mingjuan Yang, Liangzhi Zhang, Jiajie Sun, Hong Chen, Yaxi Xu, Xianyong Lan, Congjun Li   +8 more
openaire   +3 more sources

Genetic Variation in theTNFAPromoter Region andTNFAGene Expression in Subjects with Asthma

Journal of Asthma, 2013
Asthma is a chronic disease that affects millions of people. Messenger RNA (mRNA) expression of specific inflammatory markers has been associated with asthma and corticosteroid response. Tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, has been shown to have increased expression in airways of asthmatics and may be related to corticosteroid
Lanny J. Rosenwasser, Amanda K. Riffel, Bridgette L. Jones, Hongying Dai, Carrie A. Vyhlidal, Belinda K. Graham   +5 more
openaire   +3 more sources

Genetic Variants in the Promoter Region of the <i>ALOX5AP</i> Gene and Susceptibility of Ischemic Stroke

Cerebrovascular Diseases, 2011
<i>Background:</i> Despite accumulating evidence supporting the association between variants of the<i> ALOX5AP</i> gene and atherosclerotic vascular events, the precise mechanism is still unclear. No variants in the coding sequence that lead to amino acid substitution have been found.
Ruijun Ji, Jianping Jia, Jian Wu, Xin Ma, Liqing Xu, Yanli Zhang   +5 more
openaire   +3 more sources

Genetic association between interleukin-10 promoter region polymorphisms and primary Sj�gren's syndrome

Arthritis & Rheumatism, 2001
To determine whether the haplotypes formed on the basis of single-base-exchange polymorphisms at positions -1082, -819, or -592 of the interleukin-10 (IL-10) gene predispose subjects to primary Sjögren's syndrome (SS).The frequency of IL-10 polymorphisms was analyzed in 62 patients with primary SS and in 400 healthy subjects.
Janne Hulkkonen, Mikko Hurme, Amos Pasternack, M. Pertovaara, Jaakko Antonen, Nina Lahdenpohja   +5 more
openaire   +3 more sources