Results 141 to 150 of about 4,804,928 (276)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

clickBrick prompt engineering: optimizing large language model performance in clinical psychiatry. [PDF]

Npj Ment Health Res
Verhees FG, Huth F, Meyer V, Wolf F, Bauer M, Pfennig A, Ritter P, Kather JN, Wiest IC, Mikolas P.   +9 more
europepmc   +2 more sources

Pengenalan prompt engineering

Buku Pengenalan Prompt Engineering memberikan pandangan mendalam tentang konsep dan aplikasi teknik prompt dalam dunia komputasi. Penulis membahas secara rinci penggunaan dan manfaat dari prompt engineering, sebuah pendekatan yang semakin populer dalam ...
Yulius Denny Prabowo, Pandu Dwi Luhur Pambudi, Martinus Maslim   +2 more
core  

Engineering Vanderbilt; Vol. 44 No. 02, 2003

, 2003
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of Engineering.School of ...
Vanderbilt University. School of Engineering
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Prompt Engineering of Large Language Models for Medication Dose Calculation. [PDF]

Clin Pharmacol Ther
Weaver M, Petry NJ, Cauwels J, Lupu RA, Massmann A.   +4 more
europepmc   +1 more source

Engineering Vanderbilt; Vol. 47 No. 01, 2006

, 2006
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Visual prompt engineering for multimodal and irregularly sampled medical data. [PDF]

Commun Med (Lond)
Tölle M, Scharaf M, Fischer S, Reich C, Zeid S, Dieterich C, Meder B, Frey N, Wild P, Engelhardt S.   +9 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source