Results 121 to 130 of about 4,804,928 (276)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Engineering Vanderbilt; Vol. 45 No. 01, 2004

open access: yes, 2004
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Requirements Engineering Using Generative AI: Prompts and Prompting Patterns

open access: yes
[Context]: Companies are increasingly recognizing the importance of automating Requirements Engineering (RE) tasks due to their resource-intensive nature. The advent of GenAI has made these tasks more amenable to automation, thanks to its ability to understand and interpret context effectively.
Krishna Ronanki   +3 more
openaire   +3 more sources

The art of the prompt in the age of image generative AI

open access: yes
reservedLa presente tesi analizza il ruolo del prompt nell’utilizzo dell’intelligenza artificiale generativa per la creazione di immagini, con particolare attenzione ai modelli text-to-image.
DESSI', ANNA
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Prompt Engineering Guide: Animation & Game ArtRussell [PDF]

open access: yes
Prompt engineering guide for animation and game art.
Smith, Russell
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Secure Prompt Engineering Framework (SPEF)

open access: yes
Research project for the Secure Prompt Engineering Framework (SPEF), focused on mitigating prompt injection and sensitive data leakage in LLM-based ...
Gustavo Lima Viana
core   +2 more sources

Engineering Vanderbilt; Vol. 44 No. 01, 2003

open access: yes, 2003
Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core  

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