Results 111 to 120 of about 4,804,928 (276)

Optimizing ChatGPT’s Interpretation and Reporting of Delirium Assessment Outcomes: Exploratory Study

JMIR Formative Research
BackgroundGenerative artificial intelligence (AI) and large language models, such as OpenAI’s ChatGPT, have shown promising potential in supporting medical education and clinical decision-making, given their vast knowledge base ...
Yong K Choi, Shih-Yin Lin, Donna Marie Fick, Richard W Shulman, Sangil Lee, Priyanka Shrestha, Kate Santoso   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Advancing Evidence-Based Medicine for Population, Intervention, Comparison, and Outcome Element Recognition and Extraction in Medical Literature: Large Language Model Approach

Journal of Medical Internet Research
BackgroundThe exponential expansion of biomedical literature has created an urgent need for efficient methods to recognize and extract population, intervention, comparison, and outcome (PICO) elements—the foundational elements of evidence-based medicine.
Zeyuan Hao, Yifan Duan, Yu Wang
doaj   +1 more source

Early intervention and prompt corrective action in Europe [PDF]

The present crisis has revealed that, as expected, much of the safety net for handling failures in the banking system is deficient, particularly for cross-border banks, and the present problems had to be handled by a range of ad hoc measures.
Mayes, David G
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evidence-based advanced prompt engineeringin nursing research: quality analysisof ChatGPT-generated Boolean search query

Pielęgniarstwo XXI Wieku
EVIDENCE-BASED ADVANCED PROMPT ENGINEERINGIN NURSING RESEARCH: QUALITY ANALYSISOF ChatGPT-GENERATED BOOLEAN SEARCH QUERY Aim. This article explores the use of advanced prompt engineering in nursing research, with a focus on ChatGPT-generated Boolean ...
Joanna Gotlib-Małkowska, Ilona Cieślak, Mariusz Jaworski, Mariusz Panczyk   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

SAFE-PE, A Systematic Assessment Framework for Evaluating Prompt Engineering in Generative AI

Sukkur IBA Journal of Computing and Mathematical Sciences
Prompt engineering is emerging as an essential tradition to use generative AI in such domains as software, learning, health, and creativity. However, the field is yet to have a clear framework on assessing prompt quality, reliability and reproducibility.
Kashif Laeeq, Sherbano Saleem
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The influence of generative AI with prompt engineering on creative design in architectural education

Journal of Asian Architecture and Building Engineering
In architectural education, artificial intelligence (AI) has traditionally been used as a digital design tool, but its role as a pedagogical aid for enhancing creative thinking has been underexplored. This study investigates the integration of generative
Sanghee Lee, Soomin Kang
doaj   +1 more source