Results 131 to 140 of about 4,804,928 (276)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
KI Prompt Engineering Strategien
Eine Sammlung von Prompt Engineering Tipps für Large Language ...
Tjark Müller
core +1 more source
Engineering Vanderbilt; Vol. 46 No. 02, 2005
, 2005 Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Engineering Vanderbilt; Vol. 43 No. 01, 2002
, 2002 Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Engineering Vanderbilt; Vol. 50 No. 02, 2009
, 2009 Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of Engineering.Vanderbilt University.
Vanderbilt University. School of Engineering
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Engineering Vanderbilt; Vol. 46 No. 01, 2005
, 2005 Engineering Vanderbilt (formerly Engineering News) is the newsletter of the Vanderbilt University School of EngineeringSchool of ...
Vanderbilt University. School of Engineering
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source