Results 41 to 50 of about 56,942 (277)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
From prompt engineering to prompt design: Research strategies for visual generative AI
Big Data & SocietyThis demo introduces prompt design as a research approach to studying visual generative AI, distinguishing it from prompt engineering practices that focus on producing aesthetically pleasing or technically polished outputs.
Gabriele Colombo +2 more
doaj +1 more source
Prompt Engineering-Based Network Intrusion Detection System
IEEE AccessRecent advancements in generative AI and evolution of Large Language Models have opened up new paths to explore them for various applications including network attack detection.
Sunit Kumar Nandi +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
From Data Engineering to Prompt Engineering [PDF]
, 2023 Data engineering makes up a large part of the data science process. In CRISP-DM this process stage is called "data preparation". It comprises tasks such as data ingestion, data transformation and data quality assurance.
Stadi, Markus +2 more
core
Developing Prompt Engineering as a 21st-Century Skill
GiLE Journal of Skills DevelopmentArtificial intelligence (AI)-powered large language models, such as ChatGPT, are increasingly utilized in education, particularly for language learning.
Jennifer Preschern +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Tell Me Your Prompts and I Will Make Them True: The Alchemy of Prompt Engineering and Generative AI
Open PraxisThis paper explores the emerging field of prompt engineering within generative AI, emphasizing its role as a critical intersection between art and science.
Aras Bozkurt
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source