Results 51 to 60 of about 4,804,928 (276)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Integrating PICO principles into generative artificial intelligence prompt engineering to enhance information retrieval for medical librarians

Journal of the Medical Library Association
Prompt engineering, an emergent discipline at the intersection of Generative Artificial Intelligence (GAI), library science, and user experience design, presents an opportunity to enhance the quality and precision of information retrieval.
Kyle Robinson, Karen Bontekoe, Joanne Muellenbach   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Unlocking the Potential of the Prompt Engineering Paradigm in Software Engineering: A Systematic Literature Review

AI
Prompt engineering (PE) has emerged as a transformative paradigm in software engineering (SE), leveraging large language models (LLMs) to support a wide range of SE tasks, including code generation, bug detection, and software traceability.
Irdina Wanda Syahputri, Eko K. Budiardjo, Panca O. Hadi Putra   +2 more
doaj   +1 more source

Inclusive prompt engineering for large language models: a modular framework for ethical, structured, and adaptive AI [PDF]

Large language models have achieved impressive results across various tasks but remain limited in their ability to adapt ethically and structurally across diverse domains without retraining.
Alameer, Ali, Saleh Torkestani, Mohamad, Manosuri, Taha, Palaiahnakote, Shivakumara   +3 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Prompt engineering for digital mental health: a short review

Frontiers in Digital Health
Prompt engineering, the process of arranging input or prompts given to a large language model to guide it in producing desired outputs, is an emerging field of research that shapes how these models understand tasks, process information, and generate ...
Y. H. P. P. Priyadarshana, Ashala Senanayake, Zilu Liang, Ian Piumarta   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Integrating chemistry knowledge in large language models via prompt engineering

Synthetic and Systems Biotechnology
This paper presents a study on the integration of domain-specific knowledge in prompt engineering to enhance the performance of large language models (LLMs) in scientific domains.
Hongxuan Liu, Haoyu Yin, Zhiyao Luo, Xiaonan Wang   +3 more
doaj   +1 more source