Results 71 to 80 of about 370,431 (273)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Unlocking the Potential of the Prompt Engineering Paradigm in Software Engineering: A Systematic Literature Review

AI
Prompt engineering (PE) has emerged as a transformative paradigm in software engineering (SE), leveraging large language models (LLMs) to support a wide range of SE tasks, including code generation, bug detection, and software traceability.
Irdina Wanda Syahputri, Eko K. Budiardjo, Panca O. Hadi Putra   +2 more
doaj   +1 more source

A Questioning Agent for Literary Discussion [PDF]

, 2019
Developing a compelling and cohesive thesis for analytical writing can be a daunting task, even for those who have produced many written works, and finding others to engage with in literary discussion can be equally challenging.
Culkin, Robbie, Shur, Tim
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Highly efficient, dual state emission from an organic semiconductor

, 2013
We report highly efficient, simultaneous fluorescence and phosphorescence (74% yield) at room temperature from a single molecule ensemble of (BzP)PB dispersed into a polymer host. The slow phosphorescence (208 ms lifetime) is very efficient (50%) at room
Baldo, Marc A., Prins, Ferry, Reineke, Sebastian, Seidler, Nico, Tisdale, William A., Yost, Shane R.   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Evolution of the Reactor Antineutrino Flux and Spectrum at Daya Bay

, 2017
The Daya Bay experiment has observed correlations between reactor core fuel evolution and changes in the reactor antineutrino flux and energy spectrum. Four antineutrino detectors in two experimental halls were used to identify 2.2 million inverse beta ...
An, F. P., Balantekin, A. B., Band, H. R., Bishai, M., Blyth, S., Caicedo, D. A. Martinez, Cao, D., Cao, G. F., Cao, J., Chan, Y. L., Chang, J. F., Chang, Y., Chen, H. S., Chen, Q. Y., Chen, S. M., Chen, Y., Chen, Y. X., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Chukanov, A., Cummings, J. P., Ding, Y. Y., Diwan, M. V., Dolgareva, M., Dove, J., Dwyer, D. A., Edwards, W. R., Gill, R., Gonchar, M., Gong, G. H., Gong, H., Grassi, M., Gu, W. Q., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Higuera, A., Hsiung, Y. B., Hu, B. Z., Hu, T., Huang, E. C., Huang, H. X., Huang, X. T., Huang, Y. B., Huber, P., Huo, W., Hussain, G., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Jiao, J. B., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Khan, A., Kohn, S., Kramer, M., Kwan, K. K., Kwok, M. W., Langford, T. J., Lau, K., Lebanowski, L., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, C., Li, D. J., Li, F., Li, G. S., Li, Q. J., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Lin, S. K., Lin, Y. -C., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Loh, C. W., Lu, C., Lu, H. Q., Lu, J. S., Luk, K. B., Ma, X. B., Ma, X. Y., Ma, Y. Q., Malyshkin, Y., McDonald, K. T., McKeown, R. D., Mitchell, I., Nakajima, Y., Napolitano, J., Naumov, D., Naumova, E., Ngai, H. Y., Ochoa-Ricoux, J. P., Olshevskiy, A., Pan, H. -R., Park, J., Patton, S., Pec, V., Peng, J. C., Pinsky, L., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Qiu, R. M., Raper, N., Ren, J., Rosero, R., Roskovec, B., Ruan, X. C., Steiner, H., Stoler, P., Sun, J. L., Tang, W., Taychenachev, D., Treskov, K., Tsang, K. V., Tull, C. E., Viaux, N., Viren, B., Vorobel, V., Wang, C. H., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z., Wang, Z. M., Wei, H. Y., Wen, L. J., Whisnant, K., White, C. G., Whitehead, L., Wise, T., Wong, H. L. H., Wong, S. C. F., Worcester, E., Wu, C. -H., Wu, Q., Wu, W. J., Xia, D. M., Xia, J. K., Xing, Z. Z., Xu, J. L., Xu, Y., Xue, T., Yang, C. G., Yang, H., Yang, L., Yang, M. S., Yang, M. T., Yang, Y. Z., Ye, M., Ye, Z., Yeh, M., Young, B. L., Yu, Z. Y., Zeng, S., Zhan, L., Zhang, C., Zhang, C. C., Zhang, H. H., Zhang, J. W., Zhang, Q. M., Zhang, R., Zhang, X. T., Zhang, Y. M., Zhang, Y. M., Zhang, Y. X., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhou, L., Zhuang, H. L., Zou, J. H.   +204 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source