Results 101 to 110 of about 594,829 (295)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Un estudi de cas en l’anàlisi qualitativa assistida per intel·ligència artificial: l’ús de «prompts» de ChatGPT en textos de la UNESCO

Revista Catalana de Pedagogia
L’experiència que presentem exemplifica l’aplicació pràctica de diversos prompts en ChatGPT 3.5 dissenyats per dur a terme els procediments associats a l’anàlisi qualitativa d’informes i blogs de l’Organització de les Nacions Unides per a l’Educació ...
María Paz Sandín Esteban, Angelina Sánchez Martí   +1 more
doaj  

Limits of Metacognitive Prompts for Confidence Judgments in an Interactive Learning Environment

Open Education Studies
Metacognitive activities are reported to improve learning but prompts to support metacognition have only been investigated with mixed results. In the present study, metacognitive prompts for confidence judgments were implemented in a learning platform to
Klar Maria, Buchner Josef, Kerres Michael   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Private Information Retrieval From AI Chatbots via Proxy-Prompt Masking

IEEE Access
This paper proposes a privacy-preserving scheme, PromptMasking, for querying AI chatbots without disclosing users’ sensitive prompts. This scheme enables users to query AI systems without revealing their true intent by transforming sensitive ...
Shariq Bashir
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

How prompt concreteness shapes consumer food waste in restaurants: evidence from field and laboratory experiments

Frontiers in Sustainable Food Systems
IntroductionThe increasing problem of food waste has become a global issue. Displaying prompts to restaurant consumers is widely regarded as an important measure to reduce food waste, though its effectiveness remains debated.
Manze Li, Hanxiang Luo, Zhaoyang Xiang
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source