Results 101 to 110 of about 247,842 (346)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Common Acronym Words [PDF]

open access: yes, 1990
As computerized word lists become readily available to the loglogists, many of the previously difficult problems that have filled the pages of Word Ways become trivial. It is therefore interesting to begin researching problems that cannot be solved with
Cole, Chris
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Teaching Authentic English Pronounciation [PDF]

open access: yes, 2011
Most of the evidence from different research and literature indicates that learners beyond the age of puberty cannot acquire authentic pronunciation of a second language, because the articulation muscles have already lost their flexibility to be able to ...
Rashtchi, Mehrdad
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

How speaker tongue and name source language affect the automatic recognition of spoken names [PDF]

open access: yes, 2009
In this paper the automatic recognition of person names and geographical names uttered by native and non-native speakers is examined in an experimental set-up.
D'Hoore, Bart   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

BOOSTING ESL, SPEAKING AND VOCABULARY SKILLS WITH NLP: PRACTICAL TOOLS FOR THE MODERN CLASSROOM [PDF]

open access: yesЕзиков свят
Every learner encounters difficulties expressing their thoughts clearly, particularly those acquiring English as a second language. This study investigates the effect of Natural Language Processing (NLP) anchoring techniques on specific speaking sub ...
Doliana CELAJ, Greta JANI
doaj   +1 more source

Przyswajanie J3: czy nie słychać za dużo J2? [PDF]

open access: yes, 2014
For the last two decades, second language pronunciation has been in the centre of interest of numerous scholars, also in Poland. Although it was underestimated for many years, it has finally been noticed and valued, especially after the series of ...
Lipińska, Dorota
core  

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