Results 41 to 50 of about 15,378 (260)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Podcasting: An Effective Tool for Honing Language Students’ Pronunciation? [PDF]

open access: yesLanguage Learning and Technology, 2001
This paper reports on an investigation of podcasting as a tool for honing pronunciation skills in intermediate language learning. We examined the effects of using podcasts to improve pronunciation in second language learning and how students’ attitudes ...
Lara Ducate, Lara Lomicka
doaj  

The effect of synchronous and asynchronous computer-mediated communication (CMC) on learners’ pronunciation achievement

open access: yesCogent Psychology, 2021
Within the field of second language acquisition, pronunciation has received relatively little attention. This lack of research can also be seen in the general lack of systematic pedagogical materials for pronunciation training, effectively reinforcing ...
Majid Zeinali Nejad   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

SOCIOPHONETIC DESCRIPTION OF UKRAINIAN LANGUAGE OF THE PRESENT-DAY YOUTH (HISSING AND WHISTLING SOUNDS, THEIR PRE- AND POSTPOSITION)

open access: yesЗаписки з українського мовознавства, 2016
The article attempts to identify, analyse and describe the deviations that appear as a result of rules violation, the attention is drawn to the typical mistakes of pronunciation, including pronunciation of hissing sounds before whistling and whistling ...
М. Л. Дружинець
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Experimental research on English vowel errors analysis

open access: yesSHS Web of Conferences, 2016
Our paper analyzed relevant acoustic parameters of people’s speech samples and the results that compared with English standard pronunciation with methods of experimental phonetics by phonetic analysis software and statistical analysis software.
Huang Qiuhua
doaj   +1 more source

Indonesian EFL Teacher Educators’ Beliefs and Classroom Practices on The Teaching of Pronunciation: Evidence from A Pilot Study

open access: yesJurnal Ilmu Pendidikan, 2021
Oral communication among global speakers needs good pronunciation to be successful. Regardless of its important function and role, EFL teachers often ignore pronunciation in their language teaching and oftentimes they are very lenient towards ...
Made Frida Yulia, Ali Saukah
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Chinese as a Second Language Pronunciation Teaching Survey [PDF]

open access: yesJournal of the National Council of Less Commonly Taught Languages, 2018
This survey study aims to provide an overview of Chinese as a second language (CSL) pronunciation teaching in the higher educational institutions in the US. 80 respondents participated in and completed an online survey.
Chunsheng Yang, Wenhua Jin
doaj  

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