Results 61 to 70 of about 247,842 (346)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

During visual word recognition, phonology is accessed within 100 ms and may be mediated by a speech production code: evidence from magnetoencephalography [PDF]

, 2010
Debate surrounds the precise cortical location and timing of access to phonological information during visual word recognition. Therefore, using whole-head magnetoencephalography (MEG), we investigated the spatiotemporal pattern of brain responses ...
Cornelissen, Piers, Frost, Stephen, Hansen, Peter, Wheat, Katherine   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Pronunciation learning environment: EFL students’ cognitions of in-class and out-of-class factors affecting pronunciation acquisition

Theory and Practice of Second Language Acquisition, 2018
The way a foreign language (L2) learner perceives his or her educational environment may affect their processes of L2 acquisition. The aim of the study presented in this paper is to explore English as a foreign language (EFL) students’ cognitions of ...
Magdalena Szyszka
doaj  

The Analysis of English Pronunciation Errors by English Education Students of FKIP UMSU

Journal of English Education and Teaching, 2019
Pronunciation is one important thing that must be mastered by the students who studies English. Good Pronunciation makes students’ English speaking skills becomes better.
Yusriati ., Selamat Husni Hasibuan
doaj   +1 more source

Combined Acoustic and Pronunciation Modelling for Non-Native Speech Recognition [PDF]

, 2007
In this paper, we present several adaptation methods for non-native speech recognition. We have tested pronunciation modelling, MLLR and MAP non-native pronunciation adaptation and HMM models retraining on the HIWIRE foreign accented English speech ...
Bouselmi, Ghazi, Fohr, Dominique, Illina, Irina   +2 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A study of voiceless inter-dental fricative [θ], [ð] sounds and alveolar liquid [r] sound among Chinese learners of English at a higher educational institution in Malaysia

Journal of Applied Studies in Language, 2019
This study aims to investigate the pronunciation mistakes in English in accordance with the phonetic study of voiceless and voiced inter- dental fricatives [θ], [ð] and alveolar liquid [r] sounds among Chinese learners of English at University Utara ...
Mizanur Rahman, Dr. Md. Kamrul Hasan
doaj   +1 more source

Differences Between Native English-Speaking Teachers and Their Non-Native Counterparts When Evaluating Pronunciation

Profile: Issues in Teachers' Professional Development, 2020
This article is a small-scale qualitative study whose objective was to identify differences between the way in which native English teachers and their non-native Chilean counterparts assess pronunciation.
Mauricio Arcaya
doaj   +1 more source