Results 71 to 80 of about 247,842 (346)

Mispronounced lexical items in polish English of advanced learners [PDF]

, 2012
The present study is a report on an experiment in which 20 English Department students, all advanced learners of English, were recorded having been asked to read a list of diagnostic sentences containing 80 words known to be problematic for Poles in ...
Szpyra-Kozłowska, Jolanta
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Training novel phonemic contrasts: a comparison of identification and oddity discrimination training [PDF]

, 2009
High Variability Pronunciation Training (HVPT) is a highly successful alternative to ASR-based pronunciation training. It has been demonstrated that HVPT is effective in teaching the perception of non-native phonemic contrasts, and that this skill ...
Handley, Zöe, Moore, Dave, Sharples, Mike   +2 more
core  

The English pronunciation teaching in Europe survey: selected results [PDF]

, 2012
The results of EPTiES reveal interesting phenomena across Europe, despite shortcomings in terms of construction and distribution. For example, most respondents are non-native speakers of English and the majority of them rate their own mastery of English ...
Cunnigham, Una, Cunningham, Una, Curnick, Lesley, Frost, Dan, Henderson, Alice, Kautzsch, Alexander, Kirkova-Naskova, Anastazija, Levey, David, Murphy, Deirdre, Tergujeff, Elina, Waniek-Klimczak, Ewa   +10 more
core   +5 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The value of phonetics and pronunciation teaching for advanced learners of English

Linguistica, 2017
Pronunciation is an essential part of acquiring a second language, but far too often little time is spent on teaching it (Kelly 1969). It seems as if it is generally thought that pronunciation is something that will develop on its own, yet learners are ...
Gwen Brekelmans
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Assessing the Impact of Pronunciation Learning Strategy on Kurdish EFL Learners’ Pronunciation Accuracy

مجلة جامعة كويه للعلوم الانسانية والاجتماعية, 2018
The study aimed at investigating the effectiveness of pronunciation learning strategies (in favor of Covert Rehearsal Model) in helping Kurdish EFL learners to acquire accuracy in English pronunciation and detecting the most frequently used strategy ...
Himdad A. Muhammad, Dlakhshan Y. Othman
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source