Results 31 to 40 of about 1,488,747 (297)

A small molecule inhibitor of HER3: a proof-of-concept study [PDF]

Biochemical Journal, 2020
Despite being catalytically defective, pseudokinases are typically essential players of cellular signalling, acting as allosteric regulators of their active counterparts. Deregulation of a growing number of pseudokinases has been linked to human diseases, making pseudokinases therapeutic targets of interest.
Audrey Colomba, Martina Fitzek, Roger George, Gregory Weitsman, Selene Roberts, Laura Zanetti-Domingues, Michael Hirsch, Daniel J. Rolfe, Shahid Mehmood, Andrew Madin, Jeroen Claus, Svend Kjaer, Ambrosius P. Snijders, Tony Ng, Marisa Martin-Fernandez, David M. Smith, Peter J. Parker   +16 more
openaire   +4 more sources

Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa. A proof-of-concept study [PDF]

, 2018
AIM To investigate the adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.
Corleto, Vito Domenico, D'Ambra, Giancarlo, Di Giulio, Emilio, Fave, Gianfranco Delle, Lanini, Claudio, Martorelli, Michela, Pagnini, Cristiano   +6 more
core   +1 more source

Fully weekly antituberculosis regimen: a proof-of-concept study [PDF]

European Respiratory Journal, 2020
BackgroundThe World Health Organization recommends supervising the treatment of tuberculosis. Intermittent regimens have the potential to simplify the supervision and improve compliance. Our objective was to analyse the sterilising activity of once-weekly regimens based on drugs with a long half-life, bedaquiline and rifapentine, in a murine model of ...
Kort, Fatma, Fournier Le Ray, Laure, Chauffour, Aurélie, Jarlier, Vincent, Lounis, Nacer, Andries, Koen, Aubry, Alexandra, Guglielmetti, Lorenzo, Veziris, Nicolas   +8 more
openaire   +3 more sources

Pulmonary Deposition of Radionucleotide-Labeled Palivizumab: Proof-of-Concept Study

Frontiers in Pharmacology, 2020
ObjectiveCurrent prevention and/or treatment options for respiratory syncytial virus (RSV) infections are limited as no vaccine is available. Prophylaxis with palivizumab is very expensive and requires multiple intramuscular injections over the RSV ...
Anushi E. Rajapaksa, Anushi E. Rajapaksa, Anushi E. Rajapaksa, Lien Anh Ha Do, Lien Anh Ha Do, Darren Suryawijaya Ong, Darren Suryawijaya Ong, Magdy Sourial, Duncan Veysey, Richard Beare, Richard Beare, William Hughes, William Yang, Robert J. Bischof, Robert J. Bischof, Amarin McDonnell, Peter Eu, Leslie Y. Yeo, Paul V. Licciardi, Paul V. Licciardi, Edward K. Mulholland, Edward K. Mulholland, Edward K. Mulholland   +22 more
doaj   +1 more source

Single bacteria movement tracking by online microscopy--a proof of concept study. [PDF]

PLoS ONE, 2015
In this technical report we demonstrate a low-cost online unit allowing movement tracking of flagellated bacteria on a single-cell level during fermentation processes. The system's ability to distinguish different metabolic states (viability) of bacteria
Andreas Ziegler, Daniel Schock-Kusch, Dominik Bopp, Sandra Dounia, Matthias Rädle, Ulf Stahl   +5 more
doaj   +1 more source

Extending CKKW-merging to One-Loop Matrix Elements [PDF]

, 2008
We extend earlier schemes for merging tree-level matrix elements with parton showers to include also merging with one-loop matrix elements. In this paper we make a first study on how to include one-loop corrections, not only for events with a given jet ...
C.W. Bauer, C.W. Bauer, F. Krauss, J. Alwall ., J. Campbell, L. Lönnblad, Leif Lönnblad, M. Mangano, M.L. Mangano, M.L. Mangano, N. Lavesson, N. Lavesson, Nils Lavesson, P. Nason, R.Y. Zhu, S. Catani, S. Frixione, S. Frixione, S. Frixione, S. Mrenna, T. Becher, T. Sjöstrand, Z. Nagy   +22 more
core   +1 more source

Metabolomics-based biomarker discovery for bee health monitoring : a proof of concept study concerning nutritional stress in Bombus terrestris [PDF]

, 2019
Bee pollinators are exposed to multiple natural and anthropogenic stressors. Understanding the effects of a single stressor in the complex environmental context of antagonistic/synergistic interactions is critical to pollinator monitoring and may serve ...
Meeus, Ivan, Rombouts, Caroline, Smagghe, Guy, Van Meulebroek, Lieven, Vanhaecke, Lynn, Wang, Luoluo   +5 more
core   +2 more sources

Prenatal affective cognitive training: A proof-of-concept study

Neuroscience Applied, 2023
Negatively biased cognitive response to infant stimuli during pregnancy is associated with increased postpartum depression (PPD) risk. This proof-of-concept study aimed to investigate the feasibility and effects of a two-week affective cognitive training intervention on cognitive responses to emotional infant stimuli for pregnant participants at risk ...
Anne J. Bjertrup, Tue H. Petersen, Nynne Beier, Jeanne Kofoed, Ingeborg Åse Horgen, Anette Kjærbye-Thygesen, Thomas Kirkegaard, Kamilla W. Miskowiak   +7 more
openaire   +3 more sources

Using animation to teach breastfeeding physiology: a proof of concept study

International Breastfeeding Journal, 2021
Background Breastfeeding provides the optimal nourishment for infant and child health and supporting mothers to breastfeed is a global health priority.
Nicki Hartney, Dolores Dooley, Cate Nagle   +2 more
doaj   +1 more source

Unpacking the logic of mathematical statements [PDF]

, 1995
This study focuses on undergraduate students' ability to unpack informally written mathematical statements into the language of predicate calculus. Data were collected between 1989 and 1993 from 61students in six small sections of a “bridge" course ...
Selden, Annie
core   +1 more source