Results 71 to 80 of about 1,488,747 (297)

Reversed Mirror Therapy (REMIT) after Stroke—A Proof-of-Concept Study

open access: yesBrain Sciences, 2023
In mirror training (MIT), stroke patients strive to move their hands while looking at the reflected image of the unaffected one. The recruitment of the mirror neurons and visual-proprioceptive conflict are expected to facilitate the paretic voluntary ...
Luigi Tesio   +7 more
doaj   +1 more source

Constraining the geometry of AGN outflows with reflection spectroscopy [PDF]

open access: yes, 2018
We collate active galactic nuclei (AGN) with reported detections of both relativistic reflection and ultra-fast outflows. By comparing the inclination of the inner disc from reflection with the line-of-sight velocity of the outflow, we show that it is ...
Buisson, D. J. K.   +6 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Including widespread geometry formats in semantic graphs using RDF literals [PDF]

open access: yes, 2019
The exchange of building data involves both geometric and non-geometric data. A promising Linked Data approach is to embed data from existing geometry formats inside Resource Description Framework (RDF) literals.
Bonduel, Mathias   +4 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Watching Eyes at Home: A Proof-of-Concept Study

open access: yesBehavioral Sciences
Waste separation in private households remains difficult to promote, particularly in urban contexts, where anonymity limits informal social monitoring.
Sabine Windmann
doaj   +1 more source

Cellular vaccination of MLH1−/− mice – an immunotherapeutic proof of concept study

open access: yesOncoImmunology, 2018
Mismatch-repair deficiency (MMR-D) is closely linked to hypermutation and accordingly, high immunogenicity. MMR-D-related tumors thus constitute ideal vaccination targets for both therapeutic and prophylactic approaches.
Claudia Maletzki   +6 more
doaj   +1 more source

Linking the anomaly initialization approach to the mapping paradigm: a proof-of-concept study [PDF]

open access: yes, 2015
Seasonal-to-decadal predictions are initialized using observations of the present climatic state in full field initialization (FFI). Such model integrations undergo a drift toward the model attractor due to model deficiencies that incur a bias in the ...
Carrassi, Alberto   +2 more
core   +1 more source

Implementing Single Source: The STARBRITE Proof-of-Concept Study [PDF]

open access: yesJournal of the American Medical Informatics Association, 2007
Inefficiencies in clinical trial data collection cause delays, increase costs, and may reduce clinician participation in medical research. In this proof-of-concept study, we examine the feasibility of using point-of-care data capture for both the medical record and clinical research in the setting of a working clinical trial.
Rebecca, Kush   +8 more
openaire   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

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