Results 61 to 70 of about 1,041,680 (279)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

On the Complexity of Optimal k-Anonymity: A New Proof Based on Graph Coloring

open access: yesIEEE Access
Privacy is a complex balancing problem between risks and utility of data. K-anonymity, a fundamental model for preserving privacy, guarantees that an item cannot be differentiated from at least k-1 other items.
Yavuz Canbay
doaj   +1 more source

TWO-FACTOR AUTHENTICATION PROTOCOL IN ACCESS CONTROL SYSTEMS

open access: yesInformation and Telecommunication Sciences, 2023
Background. To ensure the protection of the biometric access control system used in unsecured communication channels, it is necessary to exclude the storage and transfer, transfer of biometric data as well as sequences generated on their basis. The paper
Ірина Стрелковська   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Information complexity of the AND function in the two-Party, and multiparty settings

open access: yes, 2017
In a recent breakthrough paper [M. Braverman, A. Garg, D. Pankratov, and O. Weinstein, From information to exact communication, STOC'13] Braverman et al. developed a local characterization for the zero-error information complexity in the two party model,
AA Razborov   +6 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Empirically comparing the performance of blockchain's consensus algorithms

open access: yesIET Blockchain, 2021
Blockchain‐based audit systems suffer from low scalability and high message complexity. The root cause of these shortcomings is the use of “Practical Byzantine Fault Tolerance” (PBFT) consensus protocol in those systems.
Ashar Ahmad   +5 more
doaj   +1 more source

3-manifolds efficiently bound 4-manifolds

open access: yes, 2007
It is known since 1954 that every 3-manifold bounds a 4-manifold. Thus, for instance, every 3-manifold has a surgery diagram. There are several proofs of this fact, including constructive proofs, but there has been little attention to the complexity of ...
Brock   +27 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Quantum Weakly Nondeterministic Communication Complexity

open access: yes, 2005
We study the weakest model of quantum nondeterminism in which a classical proof has to be checked with probability one by a quantum protocol. We show the first separation between classical nondeterministic communication complexity and this model of ...
D. Deutsch   +12 more
core   +4 more sources

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