Results 51 to 60 of about 310,350 (314)

The quality of reporting in case reports of permanent neonatal diabetes mellitus: a cross-sectional study

BMC Medical Research Methodology
Background Although randomized trials and systematic reviews provide the best evidence to guide medical practice, many permanent neonatal diabetes mellitus (PNDM) studies have been published as case reports.
Pengli Jia, Ling Wang, Xi Yang, WenTing Pei, Chang Xu, Jinglin Feng, Ying Han   +6 more
doaj   +1 more source

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Accelerating evidence synthesis for safety assessment through ClinicalTrials.gov platform: a feasibility study

BMC Medical Research Methodology
Background Standard systematic review can be labor-intensive and time-consuming meaning that it can be difficult to provide timely evidence when there is an urgent public health emergency such as a pandemic.
Tianqi Yu, Xi Yang, Justin Clark, Lifeng Lin, Luis Furuya-Kanamori, Chang Xu   +5 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Electrochemical disinfection of dental implants--a proof of concept. [PDF]

PLoS ONE, 2011
BACKGROUND: Peri-implantitis has gained significant clinical attention in recent years. This disease is an inflammatory reaction to microorganisms around dental implants. Due to the limited accessibility, non-invasive antimicrobial strategies are of high
Dirk Mohn, Matthias Zehnder, Wendelin J Stark, Thomas Imfeld   +3 more
doaj   +1 more source

A combined prosodic and linguistic treatment approach for language-communication skills in children with autism spectrum disorders: A proof-of-concept study

South African Journal of Childhood Education, 2016
This study aimed to determine whether the use of prosodically varied speech within a traditional language therapy framework had any effect on the listening skills, pragmatic skills and social interaction behaviour of three children with autism spectrum ...
Silva Kuschke, Bart Vinck, Salomé Geertsema   +2 more
doaj   +1 more source

Performance metamorphic testing: A Proof of concept [PDF]

Information and Software Technology, 2018
Context. Performance testing is a challenging task mainly due to the lack of test oracles, i.e. mechanisms to decide whether the performance of a program is acceptable or not because of a bug. Metamorphic testing enables the generation of test cases in the absence of an oracle by exploiting the so–called metamorphic relations between the inputs and ...
Segura Rueda, Sergio, Troya Castilla, Javier, Durán Toro, Amador, Ruiz Cortés, Antonio   +3 more
openaire   +3 more sources

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong, Min‐Hee Lee, Hiroshi Uda, Yoon Ho Hwang, Michael Behen, Aimee Luat, Csaba Juhász, Eishi Asano   +7 more
wiley   +1 more source

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial of CX-8998, a Selective Modulator of the T-Type Calcium Channel in Inadequately Treated Moderate to Severe Essential Tremor: T-CALM Study Design and Methodology for Efficacy Endpoint and Digital Biomarker Selection

Frontiers in Neurology, 2019
Background: Essential tremor (ET) is a common, progressive neurological syndrome with bilateral upper-limb dysfunction of at least 3-year duration, with or without tremor in other body locations.
Spyros Papapetropoulos, Margaret S. Lee, Stacey Boyer, Evan J. Newbold   +3 more
doaj   +1 more source