Results 51 to 60 of about 324,270 (304)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Artificial intelligence for the science of evidence synthesis: how good are AI-powered tools for automatic literature screening?

BMC Medical Research Methodology
Background Literature screening constitutes a critical component in evidence synthesis; however, it typically requires substantial time and human resources.
Minghao Ruan, Junhao Fan, Mingkai Liu, Zhengfeng Meng, Xiaohai Zhang, Chengjing Zhang   +5 more
doaj   +1 more source

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial of CX-8998, a Selective Modulator of the T-Type Calcium Channel in Inadequately Treated Moderate to Severe Essential Tremor: T-CALM Study Design and Methodology for Efficacy Endpoint and Digital Biomarker Selection

Frontiers in Neurology, 2019
Background: Essential tremor (ET) is a common, progressive neurological syndrome with bilateral upper-limb dysfunction of at least 3-year duration, with or without tremor in other body locations.
Spyros Papapetropoulos, Margaret S. Lee, Stacey Boyer, Evan J. Newbold   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The quality of reporting in case reports of permanent neonatal diabetes mellitus: a cross-sectional study

BMC Medical Research Methodology
Background Although randomized trials and systematic reviews provide the best evidence to guide medical practice, many permanent neonatal diabetes mellitus (PNDM) studies have been published as case reports.
Pengli Jia, Ling Wang, Xi Yang, WenTing Pei, Chang Xu, Jinglin Feng, Ying Han   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Accelerating evidence synthesis for safety assessment through ClinicalTrials.gov platform: a feasibility study

BMC Medical Research Methodology
Background Standard systematic review can be labor-intensive and time-consuming meaning that it can be difficult to provide timely evidence when there is an urgent public health emergency such as a pandemic.
Tianqi Yu, Xi Yang, Justin Clark, Lifeng Lin, Luis Furuya-Kanamori, Chang Xu   +5 more
doaj   +1 more source

Testing a proof of concept model for group couples counseling in family planning in Northern Uganda

The Pan African Medical Journal, 2018
INTRODUCTION: The post-conflict Acholi sub-region of Uganda is undergoing a period of transition that is influencing access, acceptability and use of family planning (FP).
Lillian Ojanduru, Dickens Ojamuge, Lauren DuComb, Jeannette Cachan, Esther Spindler   +4 more
doaj   +1 more source

The Wave Energy Converter CECO: Current Status and Future Perspectives

Proceedings, 2018
This work reviews the advances in the development of CECO, a wave energy converter (WEC) of the floating oscillating bodies subgroup that has its motions and power take-off system (PTO) restricted to an inclined direction. For this purpose, the review is
Mario López, Paulo Rosa-Santos, Francisco Taveira-Pinto, Víctor Ramos, Claudio A. Rodríguez   +4 more
doaj   +1 more source

Augmented reality-guided periacetabular osteotomy—proof of concept

Journal of Orthopaedic Surgery and Research, 2020
Background The Ganz’ periacetabular osteotomy (PAO) consists of four technically challenging osteotomies (OT), namely, supraacetabular (saOT), pubic (pOT), ischial (iOT), and retroacetabular OT (raOT).
Pascal Kiarostami, Cyrill Dennler, Simon Roner, Reto Sutter, Philipp Fürnstahl, Mazda Farshad, Stefan Rahm, Patrick O. Zingg   +7 more
doaj   +1 more source