Results 41 to 50 of about 1,488,747 (298)

Vitamin C supplementation in patients with hypothyroidism requiring high-dose levothyroxine: a proof-of-concept pilot study

Frontiers in Endocrinology
BackgroundVitamin C supplementation may enhance the absorption of levothyroxine in patients with hypothyroidism. This proof-of-concept pilot study aimed to assess the frequency of vitamin C insufficiency and evaluate the feasibility and potential ...
Adnan Agha, Bachar Afandi, Javed Yasin, Charu Sharma, Mohammad Hamdan Alshaer, Mouza Ali Saif Alshamsi, Dana Ebraheim Yaaqeib, Bayena Khamis Eshaq Alblooshi, Juma AlKaabi   +8 more
doaj   +1 more source

Medication-Wide Association Study Plus (MWAS+): A Proof of Concept Study on Drug Repurposing

Medical Sciences, 2022
The high cost and time for developing a new drug or repositioning a partially-developed drug has fueled interest in “repurposing” drugs. Drug repurposing is particularly of interest for Alzheimer’s disease (AD) or AD-related dementias (ADRD) because ...
Yan Cheng, Edward Zamrini, Ali Ahmed, Wen-Chih Wu, Yijun Shao, Qing Zeng-Treitler   +5 more
doaj   +1 more source

The health-performance framework of presenteeism: A proof-of-concept study

Frontiers in Psychology, 2022
There is emerging research that considers presenteeism as a neutral behavior that has both positive and negative predictors and outcomes for individuals and organizations.
Caroline Biron, Caroline Biron, Caroline Biron, Maria Karanika-Murray, Hans Ivers   +4 more
doaj   +1 more source

Hybrid brain-computer interface and functional electrical stimulation for sensorimotor training in participants with tetraplegia: a proof-of-concept study [PDF]

, 2015
Background and Purpose: Impaired hand function decreases quality of life in persons with tetraplegia. We tested functional electrical stimulation (FES) controlled by a hybrid brain-computer interface (BCI) for improving hand function in participants with
Aguilar, Alham Al-Sharman A, Siengsukon, Barsi, Benjamini, Brunner, Bunge, Cramer, Daly, Delorme, Dobkin, Fawcett, Grangeon, Green, Grosse-Wentrup, Gustin, Jarosiewicz, Jurkiewicz, Kokotilo, Lundell, Malouin, Marino, Mrachacz-Kersting, Mulder, Muller, Nardone, Pfurtscheller, Pfurtscheller, Rosen, Tam, Tran, Vuckovic, Waring, Waxman, Wolpaw, Wolpaw, Wrigley, Wrigley   +36 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Invariant Measures and Decay of Correlations for a Class of Ergodic Probabilistic Cellular Automata

, 2009
We give new sufficient ergodicity conditions for two-state probabilistic cellular automata (PCA) of any dimension and any radius. The proof of this result is based on an extended version of the duality concept.
A. Toom, A.L. Toom, C. Maes, C. Maes, Cristian F. Coletti, E. Domany, F.J. Lopez, L.F. Gray, N. Konno, N. Konno, P. Gacs, P. Walters, Pierre Tisseur, R.L. Dobrushin, T.M. Liggett   +14 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Leveraging recent advances in plasma biomarkers to optimize early proof of concept trials in Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION The importance of biomarkers as a primary outcome or as supportive evidence of clinical effect is rising as the field shifts toward disease‐modifying treatments and earlier intervention, because they have lower variability and can indicate ...
Garrett B. Duncan, Samuel P. Dickson, Johanne M. Kaplan, Samuel B. Johnson, Tyler M. Duke, Caleb W. Dayley, Suzanne B. Hendrix, Larry D. Altstiel, Craig H Mallinckrodt   +8 more
doaj   +1 more source

Coal discard dump rehabilitation using kenaf: Proof of concept study [PDF]

MATEC Web of Conferences
Coal discards are a side effect from coal mining and beneficiation. There are currently billions of tons of discards, with South Africa reporting over 1000 Mt, mainly fine and ultra fine coals.
Boshoff Bianca, Berner Jacques, le Roux Marco   +2 more
doaj   +1 more source

Clinical application of Vitek-derived minimum inhibitory concentration values: Proof of concept study

Southern African Journal of Infectious Diseases, 2023
Background: Minimum inhibitory concentration (MIC) values are useful in guiding appropriate antimicrobial therapy however, routine provision and interpretation of MIC values to guide clinical decision-making is challenging.
Warren Lowman
doaj   +1 more source