Results 71 to 80 of about 168,416,722 (298)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Planning of Proof by means of Sequents [PDF]
, 2010 P(論文)In a heuristic process of proof in mathematics, we try not only forward derivations from the assumptionssuch as `from A, we get B' but also backward derivations from the conclusion such as `in order to get A, we needB'.
nakanishi, Yasuo +2 more
core
Overcoming reputation and proof-of-work systems in botnets [PDF]
, 2010 Reputation and proof-of-work systems have been outlined as methods bot masters will soon use to defend their peer-to-peer botnets. These techniques are designed to prevent sybil attacks, such as those that led to the downfall of the Storm botnet.
White, Andrew +5 more
core +1 more source
Indistinguishable Proofs of Work or Knowledge [PDF]
, 2016 We introduce a new class of protocols called Proofs of Work or Knowledge PoWorKs. In a PoWorK, a prover can convince a verifier that she has either performed work or that she possesses knowledge of a witness to a public statement without the verifier being able to distinguish which of the two has taken place.
Foteini Baldimtsi +3 more
openaire +4 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 2023 Full version of Vol. 29 No. 2 (2023): A Call for Social Work Educators to Confront and Dismantle Systemic Racism WITHIN Social Work Programs (Issue ...
School of Social Work
core
Improving Transaction Speed and Scalability of Blockchain Systems via Parallel Proof of Work
Future Internet, 2020 A blockchain is a distributed ledger forming a distributed consensus on a history of transactions, and is the underlying technology for the Bitcoin cryptocurrency. Its applications are far beyond the financial sector. The transaction verification process
Shihab Shahriar Hazari, Qusay H. Mahmoud
doaj +1 more source
All Proof of Work But No Proof of Play
CoRRSpeedrunning is a competition that emerged from communities of early video games such as Doom (1993). Speedrunners try to finish a game in minimal time. Provably verifying the authenticity of submitted speedruns is an open problem. Traditionally, best-effort speedrun verification is conducted by on-site human observers, forensic audio analysis, or a ...
openaire +3 more sources
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source