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High-Dose Propafenone Overdoses: A Case with Mortality and Treatment Approaches

Eser Uyanık, Ömer Yusuf Erdurmuş
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Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6.

Chemical Research in Toxicology, 2022
Propafenone (PPF) is a class IC antidysrhythmic drug, which is commonly used for the treatment of atrial fibrillation and other supraventricular arrhythmias.
Jiaru Li, Jun-ping Shi, Chenyang Jia, Wei Li, Ying Peng, Jiang Zheng   +5 more
semanticscholar   +1 more source

Remarkably Widened QRS Complex Following a Lethal Dose of Propafenone-An Ominous Sign.

JAMA Internal Medicine, 2022
This case report describes the electrocardiogram findings of a patient in their 30s who attempted suicide by taking propafenone and presented to the emergency department with impaired consciousness and convulsions.
Jing-Xiu Li, Mu-Qiu Wang, Mingchen Gao
semanticscholar   +1 more source

Effect of CYP2D6 genetic polymorphism on peak propafenone concentration: no significant effect of CYP2D6*10.

Pharmacogenomics (London), 2020
Aim: The study aims to investigate the clinical implication of nonfunctional poor metabolizer (PM) alleles and intermediate metabolizer (IM) alleles of CYP2D6, including the CYP2D6*10 allele which shows substrate-dependent decrease in enzymatic activity,
K. Doki, Y. Shirayama, Y. Sekiguchi, K. Aonuma, Y. Kohda, M. Ieda, M. Homma   +6 more
semanticscholar   +1 more source

The outcomes of patients with septic shock treated with propafenone compared to amiodarone for supraventricular arrhythmias are related to end-systolic left atrial volume.

European heart journal. Acute cardiovascular care
BACKGROUND A recently published trial has shown no differences in outcomes between patients with new-onset supraventricular arrhythmia (SVA) in septic shock treated with either propafenone or amiodarone.
P. Waldauf, M. Pořízka, J. Horejsek, M. Otáhal, E. Svobodova, I. Jurisinova, M. Maly, T. Brožek, J. Rulíšek, P. Trachta, T. Tencer, A. Krajcova, F. Duška, M. Balík   +13 more
semanticscholar   +1 more source

Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6

Xenobiotica; the fate of foreign compounds in biological systems, 2019
1. Propafenone, an antiarrhythmic drug, is a typical human cytochrome P450 (P450) 2D6 substrate used in preclinical studies. Here, propafenone oxidation by mammalian liver microsomes was investigated in vitro. 2.
Shotaro Uehara, N. Murayama, H. Yamazaki, H. Suemizu   +3 more
semanticscholar   +1 more source