Results 71 to 80 of about 5,973 (205)

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 4646-4662, August 2026.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh   +5 more
wiley   +1 more source

Oral propafenone as treatment for incessant supraventricular and ventricular tachycardia in children

open access: yes, 1993
Incessant tachycardia, which can result in tachycardiainduced cardiomyopathy, is difficult to treat with conventional drugs. Better results are obtained with class Ic antiarrhythmic agents, but they may elicit proarrhythmias.
Bink - Boelkens, MTE, Beaufort-Crol, GCM
core   +1 more source

Prevention of atrial fibrillation episodes in patients with chronic heart failure: a new approach to the old problem

open access: yesКардиоваскулярная терапия и профилактика, 1970
Aim. To study clinical effectiveness and safety of propafenone and amiodarone in patients with arterial hypertension (AH), coronary heart disease (CHD), chronic heart failure (CHF) with preserved left ventricular (LV) systolic function, and atrial ...
Yu. M. Pozdnyakov   +3 more
doaj  

Propafenone overdose: Cardiac arrest and full recovery [PDF]

open access: yes, 2010
Intoxication caused by propafenone is very rare, and there are no known detailed epidemiological studies. We present the clinical manifestation of severe propafenone intoxication,successfully treated in a 17 year-old male. He was brought to the Intensive
Wożakowska-Kapłon, Beata; 1st Clinical Department of Cardiology, Swietokrzyskie Centre of Cardiology, Kielce, Poland   +1 more
core  

Propafenone effects on the stable structures of A beta(16-22) system

open access: yes, 2018
© 2018 Elsevier B.V. An extensive replica exchange molecular dynamics (REMD) simulation was performed to investigate the progress patterns of the molecular interactions of propafenone and Aβ16-22 system.
Ngo, Son Tung, Linh, Tran, Nguyen, Minh
core   +1 more source

Double-blind study of intravenous propafenone for paroxysmal supraventricular reentrant tachycardia [PDF]

open access: yes, 1987
Propafenone was administered during electrophysiologic testing to determine its efficacy and safety for terminating and preventing reinduction of paroxysmal supraventricular reentrant tachycardia. Four men and 10 women (mean age 50 years, range 28 to 69)
McLaran, Christopher J.   +5 more
core   +1 more source

Electrophysiologic and hemodynamic effects of intravenous propafenone in patients with recurrent ventricular tachycardia [PDF]

open access: yes, 1984
Electrophysiologic and hemodynamic studies were performed before and after intravenous infusion of a new antiarrhythmic agent, propafenone, in 28 patients with recurrent ventricular tachycardia.
Shapiro, William   +6 more
core   +1 more source

Validated capillary electrophoresis assay for the simultaneous enantioselective determination of propafenone and its major metabolites in biological samples

open access: yes, 2006
A robust, inexpensive, and fully validated CE method for the simultaneous determination of the enantiomers of propafenone (PPF), 5-hydroxy-propafenone (5OH-PPF) and N-despropyl-propafenone (NOR-PPF) in serum and in in vitro media is described.
Thormann, Wolfgang, Afshar, Minoo
core   +1 more source

Propafenone and lisinopril therapy effectiveness for sinus rhythm maintenance in patients with persistent atrial fibrillation and arterial hypertension (PROMETEY-III)

open access: yesКардиоваскулярная терапия и профилактика, 1970
Aim. To study effectiveness and safety of combined propafenone and lisinopril therapy for sinus rhythm (SR) maintenance in patients with persistent atrial fibrillation (AF) and arterial hypertension (AH). Material and methods.
R. G. Oganov   +2 more
doaj  

Propafenone in restoring sinus rhythm among patients with persistent atrial fibrillation. PROMETEY – an open, multicenter, pilot study performed in the Russian Federation

open access: yesКардиоваскулярная терапия и профилактика, 2005
Aim. To study efficacy and safety of propafenone (loading single dose of 600 mg per os) in treating atrial fibrillation (AF) paroxysms. Material and methods. The study included 233 patients with persistent AF, aged 31-62 (mean age 57.6 ± 2.8 years), from
I. G. Fomina   +3 more
doaj  

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