Results 61 to 70 of about 1,209,286 (305)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Mutual information between geomagnetic indices and the solar wind as seen by WIND : implications for propagation time estimates [PDF]
, 2005 The determination of delay times of solar wind conditions at the sunward libration point to effects on Earth is investigated using mutual information. This measures the amount of information shared between two timeseries.
R. O. Dendy +5 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Winter thunderstorms in Kamchatka [PDF]
E3S Web of Conferences, 2019 Winter thunderstorms in Kamchatka are rare meteorological phenomena. To investigate the nature of this phenomenon, time variations of quasistatic electric field and meteorological quantities at «Paratunka» observatory, IKIR FEB RAS (φ = 52:97° N; λ = 158:
Smirnov Sergey +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Flying Target Detection Technology Based on GNSS Multipath Signals
SensorsIn this study, a passive radar system that detects flying targets is developed in order to solve the problems associated with traditional flying target detection systems (i.e., their large size, high power consumption, complex systems, and poor ...
Pengfei Zhu +3 more
doaj +1 more source
Propagation-induced limits to high harmonic generation in 3D Dirac semimetals
, 2021 3D Dirac semimetals (DSMs) are promising materials for terahertz high harmonic generation (HHG). We show that 3D DSMs' high nonlinearity opens up a regime of nonlinear optics where extreme subwavelength current density features develop within nanoscale ...
Yee Sin Ang (5194844) +3 more
core +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source