Results 51 to 60 of about 474,629 (269)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Experimental Analysis of Atmospheric Ducts and Navigation Radar Over-the-Horizon Detection
Remote Sensing, 2022 Since the height of sea detection radar antenna and ship targets is relatively low, it is generally believed that its over-the-horizon detection is mainly caused by the evaporation duct at sea.
Li-Feng Huang +7 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Progress and prospects based on Qujing incoherent scatter radar measurements
地球与行星物理论评Herein, the technical characteristics and programme of Qujing incoherent scatter radar (the first one in China) are described. The measurement ability in the ionosphere, space debris, and the Moon was investigated using the data.
Jiansu Miao +4 more
doaj +1 more source
IEEE Transactions on Information Theory, 2006 We propose consensus propagation, an asynchronous distributed protocol for averaging numbers across a network. We establish convergence, characterize the convergence rate for regular graphs, and demonstrate that the protocol exhibits better scaling properties than pairwise averaging, an alternative that has received much recent attention.
Ciamac Cyrus Moallemi, Benjamin Van Roy
openaire +3 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
PAINLEV´E TEST OF A MAGNETOHYDRODYNAMICS SYSTEM [PDF]
Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2015 One approximation of magnetohydrodynamics equations, which describe the cosmic object’s magnetic field, is considered. The analytic properties of a nonlinear system are investigated by Painlev´e test.
G.M. Vodinchar +2 more
doaj +1 more source
AIP Conference Proceedings, 1998 The covariant propagator of the notivarg is found. It has the Feynmann - like form.
Bakalarska, Malgorzata, Tybor, Waclaw
openaire +2 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source