Results 71 to 80 of about 3,154,905 (317)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Flying Target Detection Technology Based on GNSS Multipath Signals

Sensors
In this study, a passive radar system that detects flying targets is developed in order to solve the problems associated with traditional flying target detection systems (i.e., their large size, high power consumption, complex systems, and poor ...
Pengfei Zhu, Qinglin Zhu, Xiang Dong, Mingchen Sun   +3 more
doaj   +1 more source

Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep [PDF]

, 2015
Propagation of slow intrinsic brain activity has been widely observed in electrophysiogical studies of slow wave sleep (SWS). However, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in terms of zero-lag ...
Abel, Achermann, Alkire, Allen, Beckmann, Biswal, Blethyn, Boly, Born, Boyle, Braun, Brown, Caminiti, Cirelli, Cirelli, Dang-Vu, Doyon, Euston, Everson, Ferezou, Florin, Fox, Franks, Franks, Gais, Graybiel, Hacker, Hacker, Hahn, Hahn, Halsband, Hayasaka, He, He, Hiltunen, Hirsch, Hobson, Horikawa, Horovitz, Horovitz, Hughes, Knowlton, König, Larson-Prior, Laureys, Lim, Loomis, Loomis, Maquet, Marshall, Mascetti, Mashour, Mashour, Massimini, Maxim, McClelland, McCormick, McCormick, McNaughton, Minka, Mitra, Mitra, Mohajerani, Mohajerani, Murphy, Nikolić, Nir, Nir, Pan, Petersen, Picchioni, Power, Rechtschaffen, Rechtschaffen, Riedner, Schneider, Seth, Sheroziya, Sirota, Soeffing, Soeffing, Steriade, Steriade, Stickgold, Stickgold, Sämann, Tagliazucchi, Tagliazucchi, Takashima, Tononi, Yuste   +90 more
core   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Determining Wind Shear Threshold by Using Historical Sounding Data in Experimental Area

Atmosphere
This paper conducts a technical study on a method for determining the occurrence threshold of wind shear based on historical sounding data. After analyzing the impact of low-altitude wind shear on aircraft flight safety, a method for determining the ...
Tingting Shu, Qinglin Zhu, Xiang Dong, Houcai Chen, Leke Lin, Xuan Liu   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PAINLEV´E TEST OF A MAGNETOHYDRODYNAMICS SYSTEM [PDF]

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2015
One approximation of magnetohydrodynamics equations, which describe the cosmic object’s magnetic field, is considered. The analytic properties of a nonlinear system are investigated by Painlev´e test.
G.M. Vodinchar, D.S. Noshenko, A.S. Perezhogin   +2 more
doaj   +1 more source

Early Detection of Fake News on Social Media Through Propagation Path Classification with Recurrent and Convolutional Networks

AAAI Conference on Artificial Intelligence, 2018
In the midst of today's pervasive influence of social media, automatically detecting fake news is drawing significant attention from both the academic communities and the general public.
Yang Liu, Y. Wu
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source