Results 71 to 80 of about 36,105,653 (286)

Time-dependent dynamical Bragg diffraction in deformed crystals by beam propagation method (BPM)

open access: yes, 2022
This paper describes how to efficiently solve time-dependent x-ray dynamic diffraction problems in distorted crystals with an FFT-based beam propagation method (FFT BPM).
Jacek Krzywinski (14356908)   +1 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Propagation-invariant space-time supermodes in a multimode waveguide

open access: yes, 2022
When an optical pulse is spatially localized in a highly multimoded waveguide, its energy is typically distributed among a multiplicity of modes, thus giving rise to a speckled transverse spatial profile that undergoes erratic changes with propagation ...
Kenneth L. Schepler (3986594)   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Numerical simulations of beam propagation through optical turbulence for high-altitude platform crosslinks [PDF]

open access: yes, 2004
In this paper we introduce a simulation method for modelling clear-air atmospheric turbulence effects for long horizontal stratospheric paths. Divergence angles of several hundred microradians in combination with link distances up to 800 km require to ...
Perlot, Nicolas   +3 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Two approaches for effective modelling of rain-rate time-series for radiocommunication system simulations [PDF]

open access: yes, 2006
The paper presents a model which allows to synthetically generate rain rate time-series for a fixed location. Rain rate time-series are very much correlated with signal attenuation in Ka band and above and, thus, enable to realistically simulate ...
Husson, Lionel   +5 more
core  

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Propagation of phase modulation signals in time-varying plasma

open access: yesAIP Advances, 2016
The effects of time-varying plasma to the propagation of phase modulation signals are investigated in this paper. Through theoretical analysis, the mechanism of the interaction between the time-varying plasma and the phase modulation signal is given.
Min Yang   +4 more
doaj   +1 more source

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