Results 91 to 100 of about 1,410 (120)

[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action

Journal of Medicinal Chemistry, 1984
Novel [(arylcarbonyl)oxy]propanolamines were synthesized and investigated as potential ultrashort-acting beta-adrenergic receptor blockers. Many of these analogues exhibited good potency and short duration. The N-ureidoalkyl analogue 85 (ACC-9089) has a potency equal to propranolol and a duration of action of about 21 min in the dog.
S T, Kam, W L, Matier, K X, Mai, C, Barcelon-Yang, R J, Borgman, J P, O'Donnell, H F, Stampfli, C Y, Sum, W G, Anderson, R J, Gorczynski   +9 more
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ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL STUDY OF 3‐PHENYL‐2‐PROPANOLAMINES

Chemischer Informationsdienst, 1979
AbstractAus Benzylchlormethyl‐keton (I) und den Grignard‐Reagenzien (II) werden die entsprechenden Chloralkohole (IIIa)‐(IIId) dargestellt und mit den sek. Aminen (IV) zu den entsprechenden Aminoalkoholen (Va)‐(Vd) umgesetzt.
H. GALONS, J.‐F. GIRARDEAU, C. COMBET FARNOUX, M. MIOCQUE, C. DUPONT, J. WEPIERRE   +5 more
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Synthesis of a novel series of (aryloxy)propanolamines: new selective .beta.2-blocking agents

Journal of Medicinal Chemistry, 1984
A new family of beta-blocking drugs is described. The originality of the new molecules lies in their functionalized hydrophobic folded structure, the basic part of which contains a benzocyclobutene ring. Excellent beta 2-blocker selectivity has been obtained with some of these compounds.
M C, Carre, A, Youlassani, P, Caubere, A, Saint-Aubin-Floch, M, Blanc, C, Advenier   +5 more
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Vanillylamide-Based Propanolamine Derivative Displays α/β-Adrenoceptor Blocking and Vasodilating Properties

Journal of Cardiovascular Pharmacology, 2002
A propanolamine derivative with vanillylamide base, KMUP 880602, was first investigated under in vivo and in vitro conditions. IV KMUP 880602 (0.1, 0.5, 1.0, and 2.0 mg/kg) produced dose-dependent hypotensive and bradycardia responses in pentobarbital-anesthetized Wistar rats. KMUP 880602 also markedly inhibited both the tachycardia effects induced by (
Jwu-Lai, Yeh, Jiunn-Ren, Wu, Chaw-Chi, Chiu, Yea-Wen, Chen, Yi-Ching, Lo, Young-Tso, Lin, Chang-Jenq, Cheng, Ing-Jun, Chen   +7 more
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Synthesis and beta-adrenergic antagonist activity of heterocyclic propanolamines.

Drug design and discovery, 1993
The synthesis and beta-adrenergic antagonist activities of a group of 1-(heteroaryloxy)- and 1-(heteroaryl)-3-alkylamino-2-propanols is described. beta 1-Adrenolytic (atria) structure-activity correlations indicated that replacement of the 1-naphthyl moiety of propranolol by a 4-quinolyl- (10), 2-quinolyl- (24), or 2-pyrimidyl- (26) heterocyclic moiety
D, Vo, M W, Wolowyk, E E, Knaus
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Synthesis and beta-adrenergic activity of a series of 3-(substituted-benzylideneaminoxy)propanolamine derivatives.

Farmaco (Societa chimica italiana : 1989), 1995
In an attempt to change the beta-adrenergic properties of completely aliphatic 3-(methyleneaminoxy)propanolamine derivatives, from antagonist to agonist, while still retaining the beta 2-selectivity, we described, in a previous paper, the synthesis of a series of such derivatives possessing a hydroxy or methoxy group linked to the aliphatic substituent
GENTILI D, LAPUCCI, ANNALINA, MACCHIA B, MACCHIA, MARCO, MARTINELLI, ADRIANO, NENCETTI, SUSANNA, ORLANDINI, ELISABETTA, FERNI G, PINZA M.   +8 more
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The molecular structure of tri-n-propanolamine borate

Inorganic and Nuclear Chemistry Letters, 1973
Zenei Taira, Kenji Osaki
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Synthesis and study of the antiviral activity of propanolamine derivatives

Pharmaceutical Chemistry Journal, 1987
L. M. M. Stankyavichene, A. P. Stankyavichyus, M. S. Sapragonene, S. P. Riselis, P. B. Terent'ev, Kh. S. Azhami, G. V. Vladyko, L. V. Korobchenko, E. I. Boreko   +8 more
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CYCLOHEXAPEPTIDYL PROPANOLAMINE COMPOUNDS

1994
BALKOVEC JAMES M, HAMMOND MILTON L, ZAMBIAS ROBERT A   +2 more
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Propanolamine derivatives

1983
BAXTER ANDREW J G, MYERS MALCOLM
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