Results 81 to 90 of about 1,410 (120)

o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as .beta.-blocking/diuretic agents

Journal of Medicinal Chemistry, 1993
A series of compounds 1b-f, 2b-f, and 3b-f having an o-chlorobenzenesulfonamidic diuretic moiety variously linked to the nitrogen side chain of the beta-blocking (aryloxy)propanolamine pharmacophore were prepared and tested for their beta 1-adrenoceptor affinity.
CECCHETTI, Violetta, FRAVOLINI, Arnaldo, SCHIAFFELLA, Fausto, TABARRINI, Oriana, Giancarlo Bruni, Giorgio Segre   +5 more
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2D QSAR of heteroaryl-substituted propanolamines as antihypertensive agents

Medicinal Chemistry Research, 2013
Propanolamines are well known for their ability to reduce blood pressure. A number of propanolamines have been approved as antihypertensive agents. A series of propanolamines was selected and different models based on multiple linear regression (MLR) were generated to find out correlation between the physicochemical parameters and the biological ...
Prasanna A. Datar, M. H. Washimkar
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.beta.-Adrenergic blocking agents. .alpha.- and .gamma.-Methyl(aryloxy)propanolamines

Journal of Medicinal Chemistry, 1981
A series of gamma-methyl- (5) and alpha-methyl(aryloxy)propanolamines (6) were synthesized and evaluated for beta-adrenergic blocking action. The binding constant (KD) was determined for compounds 5a-j on cultured C6-2B astrocytoma cells. Compounds 5a-j and 6a-e were evaluated for beta 1-antagonist action on guinea pig atria and beta 2-antagonist ...
T L, Lemke, M B, Cramer, S W, Adamski, C A, Pedone, G, Brooker   +4 more
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Synthesis and Properties of Cu(Benzoylacetone-ethanolamine) and Cu(Benzoylacetone-propanolamine)

Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1991
Abstract The Schiff base resulting from benzoylacetone and ethanolamine or propanolamine has been used to form copper(II) complexes. Cu(benzoylacetone-ethanolamine) is tetrameric with a ferromagnetic ground state. Cu(benzoylacetone-propanolamine) is dimeric with overall antiferromagnetic interaction and a singlet ground state.
K. Hines, L. J. Theriot
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Substituted propanolamines and alkylamines derived from fluoxetine as potent appetite suppressants

Bioorganic & Medicinal Chemistry, 2005
A series of propanolamine and alkylamine analogues of fluoxetine (7-26, 28-31) were synthesized and assessed for their anorexigenic and antidepressant activities. Effect of various substituents at C-4 aryl position of fluoxetine has also been studied.
Kalpana, Bhandari, Shipra, Srivastava, Girija, Shanker, Chandishwar, Nath   +3 more
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3-(Acyloxy)propanolamines: agents with β-adrenergic blocking activity

European Journal of Medicinal Chemistry, 1994
Abstract A series of totally aliphatic 3-(acyloxy)propanolamine derivatives were prepared and their pA2-values were determined employing the guinea-pig atrium. Compounds with an acetyl or methyl succinoyl half ester moiety showed a pronounced β1-adrenergic blocking activity.
J Leuschner, H Schäfer, F Leuschner
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ChemInform Abstract: Enzyme‐Catalyzed Stereoselective Synthesis of (S)‐Propanolamines.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. KAMAL, M. V. RAO
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ChemInform Abstract: Synthesis of Propanolamine Derivatives and Study of Their Antiviral Activity.

ChemInform, 1987
AbstractThe propanolamine derivatives (III), (VI), and (IX) are prepared from the epoxides (I) or the amines (IV) and (VII) as shown in the reaction scheme.
L. M. M. STANKYAVICHENE, A. P. STANKYAVICHYUS, M. S. SAPRAGONENE, S. P. RISELIS, P. B. TERENT'EV, KH. S. AZHAMI, G. V. VLADYKO, L. V. KOROBCHENKO, E. I. BOREKO   +8 more
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b-Adrenergic blocking agents. Nitrogen heteroaryl-substituted 2-propanolamines and ethanolamines

Journal of Medicinal Chemistry, 1973
Eine Reihe von Methylheterocyclen (I) wird in Form ihrer Lithiumderivate (II) mit den Aminoacetonitrilen (III) zu den Enaminen (IV) umgesetzt, die durch Hydrolyse, Reduktion mit Natriumborhydrid und hydrierende Debenzylierung in Propanolamine (VII) umgewandelt werden.
R F, Meyer, C D, Stratton, S G, Hastings, R M, Corey   +3 more
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Synthesis and beta-adrenergic antagonist activity of novel (3-cyanodihydropyridyl)propanolamines.

Drug design and discovery, 1992
The synthesis and beta-adrenergic antagonist activities of 1-(1-dihydropyridyl)-3-alkylamino-2-propanols (9-16) in which the aryloxy group of aryloxypropanolamines (1) is replaced by a 1-[2-t-(n-)butyl-3-cyano-1,2-dihydropyridyl] (9-12) or 1-[6-t-(n-)butyl-3-cyano-1,6-dihydropyridyl] (13-16) moiety is described.
D, Vo, M W, Wolowyk, E E, Knaus
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