Results 131 to 140 of about 1,467 (158)
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Journal of Medicinal Chemistry, 1986
The synthesis of [[(thienylcarbonyl)amino]phenoxy]propanolamines and their beta-adrenergic blocking and diuretic activity are described. Structure-activity relationships demonstrated that ortho substitution of the phenoxy ring with an hydrogen or an ester function leads to compounds possessing both activities.
E, Bouley +4 more
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The synthesis of [[(thienylcarbonyl)amino]phenoxy]propanolamines and their beta-adrenergic blocking and diuretic activity are described. Structure-activity relationships demonstrated that ortho substitution of the phenoxy ring with an hydrogen or an ester function leads to compounds possessing both activities.
E, Bouley +4 more
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ChemInform Abstract: SYNTHESIS AND ADRENERGIC β‐BLOCKING ACTIVITY OF SOME PROPANOLAMINE DERIVATIVES
Chemischer Informationsdienst, 1978AbstractEs werden einige Propanolamin‐Derivate wie z.B. (I) und (II) dargestellt, von denen erstere bessere β‐Blocker als Sotalol sind.
H. OBASE +7 more
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Phencyclidine-like behavioral effects of 2-methyl-3,3-diphenyl-3-propanolamine (2-MDP)
Pharmacology Biochemistry and Behavior, 19842-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) produced effects in animals similar to those produced by the dissociative anesthetics such as phencyclidine (PCP). Specifically, it shared the discriminative stimulus properties of PCP in rats trained to discriminate PCP (1 mg/kg) from saline; at higher doses, it disrupted brightness discrimination and ...
A H, Tang +3 more
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Drug design and discovery, 1992
A novel class of 1-(1-[4-phenyl(n-butyl or methyl)-3-(4,4-dimethyloxazolin-2-yl)-1,4- dihydropyridyl])-3-tert-butyl(or isopropyl)amino-2-propanols (7-12) were synthesized for evaluation as beta-adrenergic antagonists. Replacement of the naphthyloxy moiety of propranolol by a 1-[1-(4-n-butyl)-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyrid yl] group ...
D, Vo, M W, Wolowyk, E E, Knaus
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A novel class of 1-(1-[4-phenyl(n-butyl or methyl)-3-(4,4-dimethyloxazolin-2-yl)-1,4- dihydropyridyl])-3-tert-butyl(or isopropyl)amino-2-propanols (7-12) were synthesized for evaluation as beta-adrenergic antagonists. Replacement of the naphthyloxy moiety of propranolol by a 1-[1-(4-n-butyl)-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyrid yl] group ...
D, Vo, M W, Wolowyk, E E, Knaus
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Pharmacokinetic Studies on Some Novel (2-Nitro-1-Imidazolyl) Propanolamine Radiosensitizers
1982One area of current interest in radiosensitizer development is in the use of nitroimidazoles of a more polar nature than misonida-zole, combining the benefits of a shorter half-life, and thus reduced tissue exposure, which has been correlated with the neuropathy observed with misonidazole (1), while also minimising brain penetration through the blood ...
M. R. L. Stratford +3 more
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Farmaco (Societa chimica italiana : 1989), 1995
In an attempt to change the beta-adrenergic properties of completely aliphatic 3-(methyleneaminoxy)propanolamine derivatives, from antagonist to agonist, while still retaining the beta 2-selectivity, we described, in a previous paper, the synthesis of a series of such derivatives possessing a hydroxy or methoxy group linked to the aliphatic substituent
GENTILI D +8 more
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In an attempt to change the beta-adrenergic properties of completely aliphatic 3-(methyleneaminoxy)propanolamine derivatives, from antagonist to agonist, while still retaining the beta 2-selectivity, we described, in a previous paper, the synthesis of a series of such derivatives possessing a hydroxy or methoxy group linked to the aliphatic substituent
GENTILI D +8 more
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The molecular structure of tri-n-propanolamine borate
Inorganic and Nuclear Chemistry Letters, 1973Zenei Taira, Kenji Osaki
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Synthesis and study of the antiviral activity of propanolamine derivatives
Pharmaceutical Chemistry Journal, 1987L. M. M. Stankyavichene +8 more
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