Results 121 to 130 of about 1,585 (172)
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2D QSAR of heteroaryl-substituted propanolamines as antihypertensive agents
Medicinal Chemistry Research, 2013Propanolamines are well known for their ability to reduce blood pressure. A number of propanolamines have been approved as antihypertensive agents. A series of propanolamines was selected and different models based on multiple linear regression (MLR) were generated to find out correlation between the physicochemical parameters and the biological ...
Prasanna A Datar
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Journal of Medicinal Chemistry, 1993
A series of compounds 1b-f, 2b-f, and 3b-f having an o-chlorobenzenesulfonamidic diuretic moiety variously linked to the nitrogen side chain of the beta-blocking (aryloxy)propanolamine pharmacophore were prepared and tested for their beta 1-adrenoceptor affinity.
Violetta Cecchetti +2 more
exaly +4 more sources
A series of compounds 1b-f, 2b-f, and 3b-f having an o-chlorobenzenesulfonamidic diuretic moiety variously linked to the nitrogen side chain of the beta-blocking (aryloxy)propanolamine pharmacophore were prepared and tested for their beta 1-adrenoceptor affinity.
Violetta Cecchetti +2 more
exaly +4 more sources
Enzyme catalyzed stereoselective synthesis of (S)-propanolamines
Tetrahedron: Asymmetry, 1994Abstract Stereoselective synthesis of (S)-propanolamines has been carried out by the ring opening of racemic epoxides with 2-propylamine in presence of lipases and subtilisin. The effect of solvent towards selectivity has also been studied.
Ahmed Kamal, Maddamsetty V Rao
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Choline cannot be replaced by propanolamine in mice
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007Choline is an important nutrient for humans and animals. Animals obtain choline from the diet and from the catabolism of phosphatidylcholine made by phosphatidylethanolamine N-methyltransferase (PEMT). The unique model of complete choline deprivation is Pemt(-/-) mice that are fed a choline-deficient diet.
Zhaoyu, Li, Dennis E, Vance
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.beta.-Adrenergic blocking agents. .alpha.- and .gamma.-Methyl(aryloxy)propanolamines
Journal of Medicinal Chemistry, 1981A series of gamma-methyl- (5) and alpha-methyl(aryloxy)propanolamines (6) were synthesized and evaluated for beta-adrenergic blocking action. The binding constant (KD) was determined for compounds 5a-j on cultured C6-2B astrocytoma cells. Compounds 5a-j and 6a-e were evaluated for beta 1-antagonist action on guinea pig atria and beta 2-antagonist ...
T L, Lemke +4 more
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THE REACTION OF PHOSPHORUS TRICHLORIDE WITH PROPANOLAMINE-1.3
Phosphorus, Sulfur, and Silicon and the Related Elements, 1994Abstract The reaction of PCl3 with propanolamine-1.3 in the presence of Net3 was studied and found to form two heterocyclic compounds, the 2-chloro-3-dichlorophosphanyl-1.3.2-oxazaphosphorinane and the 2-aminopropoxy-1.3.2-oxazaphosphorinane, which could be isolated and characterized.
Cornelia Mundt, Lothar Riesel
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ChemInform Abstract: Enzyme‐Catalyzed Stereoselective Synthesis of (S)‐Propanolamines.
ChemInform, 1995AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. KAMAL, M. V. RAO
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3-(Acyloxy)propanolamines: agents with β-adrenergic blocking activity
European Journal of Medicinal Chemistry, 1994Abstract A series of totally aliphatic 3-(acyloxy)propanolamine derivatives were prepared and their pA2-values were determined employing the guinea-pig atrium. Compounds with an acetyl or methyl succinoyl half ester moiety showed a pronounced β1-adrenergic blocking activity.
J Leuschner, H Schäfer, F Leuschner
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Substituted propanolamines and alkylamines derived from fluoxetine as potent appetite suppressants
Bioorganic & Medicinal Chemistry, 2005A series of propanolamine and alkylamine analogues of fluoxetine (7-26, 28-31) were synthesized and assessed for their anorexigenic and antidepressant activities. Effect of various substituents at C-4 aryl position of fluoxetine has also been studied.
Kalpana, Bhandari +3 more
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b-Adrenergic blocking agents. Nitrogen heteroaryl-substituted 2-propanolamines and ethanolamines
Journal of Medicinal Chemistry, 1973Eine Reihe von Methylheterocyclen (I) wird in Form ihrer Lithiumderivate (II) mit den Aminoacetonitrilen (III) zu den Enaminen (IV) umgesetzt, die durch Hydrolyse, Reduktion mit Natriumborhydrid und hydrierende Debenzylierung in Propanolamine (VII) umgewandelt werden.
R F, Meyer +3 more
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