Results 141 to 150 of about 1,585 (172)

ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL STUDY OF 3‐PHENYL‐2‐PROPANOLAMINES

Chemischer Informationsdienst, 1979
AbstractAus Benzylchlormethyl‐keton (I) und den Grignard‐Reagenzien (II) werden die entsprechenden Chloralkohole (IIIa)‐(IIId) dargestellt und mit den sek. Aminen (IV) zu den entsprechenden Aminoalkoholen (Va)‐(Vd) umgesetzt.
H. GALONS, J.‐F. GIRARDEAU, C. COMBET FARNOUX, M. MIOCQUE, C. DUPONT, J. WEPIERRE   +5 more
openaire   +1 more source

Phencyclidine-like behavioral effects of 2-methyl-3,3-diphenyl-3-propanolamine (2-MDP)

Pharmacology Biochemistry and Behavior, 1984
2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) produced effects in animals similar to those produced by the dissociative anesthetics such as phencyclidine (PCP). Specifically, it shared the discriminative stimulus properties of PCP in rats trained to discriminate PCP (1 mg/kg) from saline; at higher doses, it disrupted brightness discrimination and ...
A H, Tang, A A, Cangelosi, R A, Code, S R, Franklin   +3 more
openaire   +2 more sources

ChemInform Abstract: Synthesis of Propanolamine Derivatives and Study of Their Antiviral Activity.

ChemInform, 1987
AbstractThe propanolamine derivatives (III), (VI), and (IX) are prepared from the epoxides (I) or the amines (IV) and (VII) as shown in the reaction scheme.
L. M. M. STANKYAVICHENE, A. P. STANKYAVICHYUS, M. S. SAPRAGONENE, S. P. RISELIS, P. B. TERENT'EV, KH. S. AZHAMI, G. V. VLADYKO, L. V. KOROBCHENKO, E. I. BOREKO   +8 more
openaire   +1 more source

ChemInform Abstract: SYNTHESIS AND ADRENERGIC β‐BLOCKING ACTIVITY OF SOME PROPANOLAMINE DERIVATIVES

Chemischer Informationsdienst, 1978
AbstractEs werden einige Propanolamin‐Derivate wie z.B. (I) und (II) dargestellt, von denen erstere bessere β‐Blocker als Sotalol sind.
H. OBASE, H. TATSUNO, K. GOTO, K. SHIGENOBU, Y. KASUYA, Y. YAMADA, K. FUJII, S. YADA   +7 more
openaire   +1 more source

Synthesis of carbon‐14 labeled (±)‐2‐methyl‐3,3‐diphenyl‐3‐propanolamine (2‐MDP)

Journal of Labelled Compounds and Radiopharmaceuticals, 1988
AbstractThe preparation of 14C labeled (±)‐2‐methyl‐3,3‐diphenyl‐3‐propanolamine (3) from [14C]‐carbonyl‐benzophenone is described.
Brian De Costa, Andrew Thurkauf, Arthur E. Jacobson, Kenner C. Rice   +3 more
openaire   +1 more source

Synthesis of a novel series of (aryloxy)propanolamines: new selective .beta.2-blocking agents

Journal of Medicinal Chemistry, 1984
A new family of beta-blocking drugs is described. The originality of the new molecules lies in their functionalized hydrophobic folded structure, the basic part of which contains a benzocyclobutene ring. Excellent beta 2-blocker selectivity has been obtained with some of these compounds.
M C, Carre, A, Youlassani, P, Caubere, A, Saint-Aubin-Floch, M, Blanc, C, Advenier   +5 more
exaly   +3 more sources

Synthesis and beta-adrenergic antagonist activity of heterocyclic propanolamines.

Drug design and discovery, 1993
The synthesis and beta-adrenergic antagonist activities of a group of 1-(heteroaryloxy)- and 1-(heteroaryl)-3-alkylamino-2-propanols is described. beta 1-Adrenolytic (atria) structure-activity correlations indicated that replacement of the 1-naphthyl moiety of propranolol by a 4-quinolyl- (10), 2-quinolyl- (24), or 2-pyrimidyl- (26) heterocyclic moiety
D, Vo, M W, Wolowyk, E E, Knaus
openaire   +1 more source

Pharmacokinetic Studies on Some Novel (2-Nitro-1-Imidazolyl) Propanolamine Radiosensitizers

1982
One area of current interest in radiosensitizer development is in the use of nitroimidazoles of a more polar nature than misonida-zole, combining the benefits of a shorter half-life, and thus reduced tissue exposure, which has been correlated with the neuropathy observed with misonidazole (1), while also minimising brain penetration through the blood ...
M. R. L. Stratford, A. I. Minchinton, F. A. Stewart, V. S. Randhawa   +3 more
openaire   +1 more source

ChemInform Abstract: β‐ADRENERGIC BLOCKING AGENTS. α‐ AND Γ‐METHYL(ARYLOXY)PROPANOLAMINES

Chemischer Informationsdienst, 1982
Abstractα‐Naphthol und Phenole (I) reagieren mit dem Epoxid (II) und Aminen zu den Aminoethern (III) und (IV), die durch Säulenchromatographie an Kieselgel voneinander getrennt werden können.
T. L. LEMKE, M. B. CRAMER, S. W. ADAMSKI, C. A. PEDONE, G. BROOKER   +4 more
openaire   +1 more source

Synthesis and beta-adrenergic antagonist activity of novel (3-oxazolinyl-1,4-dihydropyridyl) propanolamines.

Drug design and discovery, 1992
A novel class of 1-(1-[4-phenyl(n-butyl or methyl)-3-(4,4-dimethyloxazolin-2-yl)-1,4- dihydropyridyl])-3-tert-butyl(or isopropyl)amino-2-propanols (7-12) were synthesized for evaluation as beta-adrenergic antagonists. Replacement of the naphthyloxy moiety of propranolol by a 1-[1-(4-n-butyl)-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyrid yl] group ...
D, Vo, M W, Wolowyk, E E, Knaus
openaire   +2 more sources