Results 41 to 50 of about 1,956 (206)

Experience (Mostly Negative) with the Use of Sympathomimetic Agents for Weight Loss

Journal of Obesity, Volume 2011, Issue 1, 2011., 2011
Sympathomimetic agents have a poor history of long‐term success in the treatment of obesity. From earlier experiences with amphetamine and its analogs, to more recent drugs with direct effects on adrenergic receptors or indirect effects from release of catecholamines or inhibition of reuptake, cardiovascular toxicity (strokes and cardiac arrhythmias ...
Mario A. Inchiosa Jr., A. Halpern
wiley   +1 more source

Nickel‐Catalyzed O‐Arylation of N‐Protected Amino Alcohols with (Hetero)aryl Chlorides

Chemistry – A European Journal, Volume 31, Issue 10, February 17, 2025.
The first effective base metal‐catalyzed protocol for C−O cross‐coupling of primary, secondary, and tertiary alcohol‐containing N‐Boc protected amino alcohols with (hetero)aryl chlorides, affording access to new and useful N‐protected aryloxyamine compounds, is reported.
Kathleen M. Morrison, Emily C. Jackson, Erika M. H. Elliott, Mark Stradiotto   +3 more
wiley   +1 more source

Straightforward Synthesis of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols – Accessing Fluorinated Derivatives of Commercialized Beta‐Blockers

European Journal of Organic Chemistry, Volume 27, Issue 35, September 16, 2024.
An array of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols were synthesized using iodohydroxylation of gem‐difluorinated allyl aryl ethers followed by epoxidation and ring‐opening with an amine in a one‐pot/two‐step fashion. This approach allows the synthesis of a set of gem‐difluorinated derivatives of commercialized beta‐blockers.
Jan‐Ole Moritz, Shuang Liu, Katharina Konieczny, Dirk Michalik, Udo Kragl, Helfried Neumann, Matthias Beller   +6 more
wiley   +1 more source

Eugenol ve timol içeren yeni oksipropanolamin türevlerinin sentezi ve antibakteriyel özelliklerinin araştırılması [PDF]

, 2019
06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması ...
Kestane, Ali
core  

Crystal structures, electron spin resonance, and thermogravimetric analysis of three mixed‐valence copper cyanide polymers

Acta Crystallographica Section C, Volume 80, Issue 6, Page 212-220, June 2024.
The crystal structures of three mixed‐valence copper cyanide polymers with similar polymeric CuCN networks are described, together with the results of electron spin resonance and thermogravimetric analyses.The crystal structures of three mixed‐valence copper cyanide alkanolamine polymers are presented, together with thermogravimetric analysis (TGA) and
Peter W. R. Corfield, Ahmed Elsayed, Tristan DaCunha, Christopher Bender   +3 more
wiley   +1 more source

Oxa-Michael Addition to alpha,beta-Unsaturated Nitriles:An Expedient Route to gamma-Amino Alcohols and Derivatives [PDF]

, 2018
Water addition to alpha,beta-unsaturated nitriles would give facile access to the -hydroxy-nitriles, which in turn can be hydrogenated to the gamma-amino alcohols.
de Vries, Johannes G., Guo, Beibei, Otten, Edwin, Zijlstra, Douwe S.   +3 more
core   +1 more source

I. Preparation of Strategic Synthetic Building Blocks for World Health Organization Essential Medicines. II. Applying the Principles of Process Intensification to the Synthesis of Fluoroquinolone Antibiotics. [PDF]

, 2023
The synthesis of active pharmaceutical ingredients is often a time-consuming and expensive process. Due to the nature of pharmaceutical manufacturing, these costs are carried forward to the final purchase price by the consumer.
Noble, Jeffrey M
core   +2 more sources

Evaluation of fresh state, rheological properties, and compressive strength performance of cementitious system with grinding aids

Journal of Applied Polymer Science, Volume 141, Issue 15, April 15, 2024.
Synergic Interaction of Amine Based GAs with PCE cement systems. Abstract Grinding aids (GA) affect the fresh and hardened state properties of cement systems in addition to the economic and ecological advantages they provide. Nevertheless, there is not enough information in the literature regarding the effect of GA utilization on the rheological ...
Yahya Kaya, Veysel Kobya, Ali Mardani
wiley   +1 more source

Effects of Esmolol, Lidocaine and Fentanyl on P Wave Dispersion, QT, QTc Intervals and Hemodynamic Responses to Endotracheal Intubation During Propofol Induction: a Comparative Study

Brazilian Journal of Anesthesiology, 2013
Background and objectives: In our study we aimed to investigate the effect of esmolol, lidocaine and fentanyl on P-wave dispersion (Pwd), QT and corrected QT (QTc) durations and hemodynamic responses to endotracheal intubation during propofol induction ...
Volkan Hancı, Serhan Yurtlu, Turgut Karabağ, Dilek Okyay, Sedat Hakimoğlu, Gülay Kayhan, Çağatay Büyükuysal, Hilal Ayoğlu, Işıl Özkoçak Turan   +8 more
doaj  

Characterization of BU09059:A novel potent selective κ-receptor antagonist [PDF]

, 2014
[Image: see text] Kappa-opioid receptor (κ) antagonists are potential therapeutic agents for a range of psychiatric disorders. The feasibility of developing κ-antagonists has been limited by the pharmacodynamic properties of prototypic κ-selective ...
Bailey, Sarah J, Casal-Dominguez, Joseph J, Clarke, Mary J, Furkert, Daniel, Husbands, Stephen M, Ostovar, Mehrnoosh, Teintang, Linnea, Traynor, John R   +7 more
core   +1 more source