Results 51 to 60 of about 1,079 (262)

A Versatile DNA‐Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity

Advanced Science, EarlyView.
We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong, Sunny A. Tang, Yifan Deng, Zhihan Nan, Alison X. Gao, Gregory A. Michaud, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Shuang Liu, William J. Gibson, Stuart L. Schreiber   +11 more
wiley   +1 more source

Enantioseparation of 1-substituted 3-arylseleno-2-propanols onPolysaccharide Tris(3,5-dimethylphenylcarbamate)Chiral Stationary Phases

, 2005
采用Chiralcel OD H和Chiralpak AD H手性柱,研究5种新近合成的外消旋双芳基硒代甘油硫醚和 4 种芳基硒代甘油烷氧醚对映体的高效液相色谱拆分方法.对比这两种手性固定相、异丙醇和乙醇流动相调节剂、以及样品结构对硒代甘油醚色谱拆分的影响.除样品(1c)外,其他8个外消旋硒代甘油醚样品均可达到基线拆分.The enantiomer separation of nine pairs of racemic 1-arylthio-3-arylseleno -2-propanols and 1-
徐秀青, 王进贤, 阮源萍
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Valorization of glycerol into new bulk chemicals : hydrogen, propylene glycol and propanols [PDF]

, 2019
In processing of biodiesel, about 10% of the total product released is glycerol. If this was an added value in the early industrialization of the process, nowadays it’s an issue.
Muscolino, Federico
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Conformation of 1-aryl-2-aryloxy-1-propanols: threo-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1-propanol

, 2008
The title compound, C17H20O5, (I), is structurally related to naturally occurring 1-aryl-2-aryloxy-1-propanols. Such compounds are of interest as lignin models, and neolignans of this type have been detected in a large number of plants.
Lundquist, Knut, Langer, Vratislav,, Lundquist, Knut,, Langer, Vratislav, Li, Shiming,, Li, Shiming   +5 more
core   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Synthesis and conformation analysis of 1-dialkilamino-2-(2'-cyclohexen)-il-2-propanols

, 2003
The reaction between 3-cyclohexenylmagnesiumhaloides and dialkylaminoaceton in one stage is stereospecific and results in formation of 1-dialkiloamino-2-(2'-cyclohexen)-il-2-propanols that can be explained by action of intermolecular H-bond OH…N.
Цмур, Ю.Ю.
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Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Addition of Diethylzinc to Dicobalt Hexacarbonyl Complexes of α,β-Acetylenic Aldehydes with Virtually Complete Enantioselectivity. A Formal Synthesis of (+)-Incrustoporin

, 2016
The addition of diethylzinc to dicobalt hexacarbonyl complexes of acetylenes mediated by (R)-2-piperidino-1,1,2-triphenylethanol takes place with very high enantioselectivity (96−99% ee) to afford the S enantiomers of dicobalt hexacarbonyl complexes of 1-
Montserrat Fontes (2711029), Lluís Solà (2644477), Katamreddy Subba Reddy (2429542), Anton Vidal-Ferran (1416652), Antoni Riera (1367805), Miquel A. Pericàs (2442931), Xavier Verdaguer (1367802)   +6 more
core   +1 more source

Solvent‐Free Synthesis of Ultrabright Carbon Dots With Near‐Unity Quantum Yield for High‐Performance Light‐Emitting Diodes

Advanced Science, EarlyView.
A rational, solvent‐free synthesis utilizing 2,6‐diaminonaphthalene produces ultrabright green‐emissive carbon dots. Regulated by a self‐limiting oxidative capping mechanism, excitons undergo ultrafast intra‐particle funneling from the nitrogen‐doped carbon core to emissive surface traps.
Hyeonjin Park, Su Hwan Lee, Sejeong Seo, Soye Park, Soo min Ji, Hyunda Jo, Sehyeon Park, Young‐Hoon Kim, Woosung Kwon   +8 more
wiley   +1 more source

Synthesis of substituted tetrahydro-1,3-oxazines

, 2020
A number of mono-, di-, tri-, and tetrasubstituted tetrahydro-1,3-oxazines were synthesized by the reaction of 3-amino- and 3-methylamino-1-propanols with aldehydes.
Boiko I., Zhuk O., Samitov Y., Kazantsev Y., Malina Y., Unkovskii B.   +5 more
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