Results 41 to 50 of about 1,861,153 (306)
Epidemiology, Biostatistics and Public Health, 2022 Background. In observational research on causal effects, missing data and confounding are very common problems. Multiple imputation and propensity score methods have gained increasing interest as methods to deal with these, but despite their ...
Bas BL Penning de Vries +1 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Balancing Score Adjusted Targeted Minimum Loss-based Estimation
Journal of Causal Inference, 2015 Adjusting for a balancing score is sufficient for bias reduction when estimating causal effects including the average treatment effect and effect among the treated.
Lendle Samuel David +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Frontiers in Surgery, 2022 ObjectiveTo investigate the factors affecting the timing and prognosis of early tracheostomy in multiple rib fracture patients.MethodsA retrospective case-control study was used to analyze the clinical data of 222 patients with multiple rib fractures who
Bing Zhang +8 more
doaj +1 more source
Specification tests for the propensity score [PDF]
Journal of Econometrics, 2019 This paper proposes new nonparametric diagnostic tools to assess the asymptotic validity of different treatment effects estimators that rely on the correct specification of the propensity score. We derive a particular restriction relating the propensity score distribution of treated and control groups, and develop specification tests based upon it. The
Sant'Anna, Pedro H. C., Song, Xiaojun
openaire +3 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Evaluating Continuous Training Programs Using the Generalized Propensity Score [PDF]
This paper assesses the dynamics of treatment effects arising from variation in the duration of training. We use German administrative data that have the extraordinary feature that the amount of treatment varies continuously from 10 days to 395 days (i.e.
Jochen Kluve +3 more
core +2 more sources
PSL Quarterly Review, 2019 This paper evaluates the impact of the US African Growth and Opportunity Act (AGOA) trade arrangement on the growth of exports from Sub-Saharan African (SSA) countries.
Busani Moyo +2 more
doaj +1 more source