Results 41 to 50 of about 393,333 (294)

Some More Density Results for Proper Efficiencies

open access: yesJournal of Mathematical Analysis and Applications, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bednarczuk, E.M., Song, W.
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Model Order Reduction of Non-Linear Magnetostatic Problems Based on POD and DEI Methods [PDF]

open access: yes, 2014
In the domain of numerical computation, Model Order Reduction approaches are more and more frequently applied in mechanics and have shown their efficiency in terms of reduction of computation time and memory storage requirements. One of these approaches,
CLENET, Stephane, HENNERON, Thomas
core   +1 more source

Globally proper efficiency of set optimization problems based on the certainly set less order relation [PDF]

open access: yes, 2023
In this paper, we investigate the globally proper efficiency of set optimization problems. Firstly, we use the so-called certainly set less order relation to define a new kind of set order relation.
Zhou, Zhiang   +2 more
core   +1 more source

PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA

open access: yesDrug Delivery, 2023
Inhalable messenger RNA (mRNA) has demonstrated great potential in therapy and vaccine development to confront various lung diseases. However, few gene vectors could overcome the airway mucus and intracellular barriers for successful pulmonary mRNA ...
Yingying Xu   +9 more
doaj   +1 more source

Sample-Efficient Omniprediction for Proper Losses

open access: yesCoRR
We consider the problem of constructing probabilistic predictions that lead to accurate decisions when employed by downstream users to inform actions. For a single decision maker, designing an optimal predictor is equivalent to minimizing a proper loss function corresponding to the negative utility of that individual.
Isaac Gibbs, Ryan J. Tibshirani
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Application of PGD separation of space to create a reduced-order model of a lithium-ion cell structure

open access: yesFrontiers in Materials, 2023
Lithium-ion cells can be considered a laminate of thin plies comprising the anode, separator, and cathode. Lithium-ion cells are vulnerable toward out-of-plane loading.
Alexander Schmid   +11 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

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