Results 71 to 80 of about 1,819,004 (284)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A system dynamics approach for improving efficiency of total quality management (TQM) [PDF]

, 2009
This paper investigates a system dynamics model to evaluate efficiency of Total Quality Management (TQM) for the enterprise. Previous studies reveal that, quality efforts, information symmetry, the gap between performance and the inferences from ...
Bakhsha, Arash, Cossío Silva, Francisco José (Coordinador), Ebrahimi Taleghani, Ahamad, Seyed-Hosseini, Seyed Mohammad   +3 more
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Isolated minimizers, proper efficiency and stability for C0,1 constrained vector optimization problems [PDF]

In this paper we consider the vector optimization problem minC f(x), g(x) 2 -K, where f : Rn ! Rm and g : Rn Rp are C0,1 functions and C Rm and K Rp are closed convex cones.
Ginchev Ivan, Guerraggio Angelo, Rocca Matteo   +2 more
core  

Random Walks with Long-Range Self-Repulsion on Proper Time

, 1992
We introduce a model of self-repelling random walks where the short-range interaction between two elements of the chain decreases as a power of the difference in proper time. Analytic results on the exponent $\nu$ are obtained. They are in good agreement
A. I. Larkin, A. J. Guttmann, A. Weinrib, Andrea Pelissetto, B. MacDonald, B. Nienhuis, D. Brydges, E. J. Janse van Rensburg, E. Marinari, Giorgo Parisi, H. Meirovitch, J. C. Guillou Le, J. Cloiseaux des, J. Cloiseaux des, J. Cloiseaux des, J. Sak, J.-P. Bouchaud, K. Suzuki, K. Symanzik, M. Daoud, M. Lal, N. Madras, P. G. Gennes de, P. J. Flory, P. Pfeuty, Ph. Forcrand de, S. Caracciolo, S. Caracciolo, S. Caracciolo, S. F. Edwards, Sergio Caracciolo, V. J. Emery, Y. Oono, Z. Alexandrowicz, Z. Alexandrowicz   +34 more
core   +1 more source

A Robust Adaptive One‐Sample‐Ahead Preview Super‐Twisting Sliding Mode Controller

International Journal of Adaptive Control and Signal Processing, EarlyView.
Block Diagram of the Robust Adaptive One‐Sample‐Ahead Preview Super‐Twisting Sliding Mode Controller. ABSTRACT This article introduces a discrete‐time robust adaptive one‐sample‐ahead preview super‐twisting sliding mode controller. A stability analysis of the controller by Lyapunov criteria is developed to demonstrate its robustness in handling both ...
Guilherme Vieira Hollweg, Paulo Jefferson Dias de Oliveira Evald, Shivam Chaturvedi, Hilton Abilio Gründling, Rodrigo Varella Tambara, Wencong Su   +5 more
wiley   +1 more source

Analysis of proper ink management impact on overall environmental equipment efficiency for sustainability

Scientific Reports
Printing as a process itself generates many environmental concerns. The paper addresses ink management in terms of environmental issues in the label printing industry, focusing on its environmental implications.
Krzysztof Krystosiak, Aldona Kluczek, Wojciech Werpachowski   +2 more
doaj   +1 more source

High power surface emitting terahertz laser with hybrid second- and fourth-order Bragg gratings

Nature Communications, 2018
Proper design of the gratings can enhance the efficiency of distributed-feedback and quantum cascade lasers. Here, Jin et al. use a hybrid grating system that superposes second- and fourth-order Bragg gratings and achieve high radiative efficiency and a ...
Yuan Jin, Liang Gao, Ji Chen, Chongzhao Wu, John L. Reno, Sushil Kumar   +5 more
doaj   +1 more source

Experimental Evaluation of 100Cr6 Steel Microindented Surfaces Under Lubricated Nonconformal Point Contacts

Advanced Engineering Materials, EarlyView.
The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi, Pasquale Guglielmi, Gianfranco Palumbo, Giuseppe Carbone   +3 more
wiley   +1 more source

Innovative Processing of Compacted Waste Aluminum Alloy Powders via Controlled Remelting and Solidification

Advanced Engineering Materials, EarlyView.
This study demonstrates an efficient recycling route for out‐of‐spec AlSi10Mg atomized powders through compaction and arc remelting followed by suction casting. By correlating compaction load, cooling rate, and resulting microstructure, we show that intermediate pressures (50–80 kN) and rapid cooling refine dendrites, reduce porosity, and enhance ...
Mila Christy de Oliveira, Marcella Gaute Cavalcante Xavier, Abdoul‐Aziz Bogno, Piter Gargarella, José Eduardo Spinelli   +4 more
wiley   +1 more source