Results 71 to 80 of about 393,333 (294)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Ownership, Contractual Practices and Technical Efficiency: The Case of Urban Public Transport in France [PDF]

This paper investigates the impact of ownership structure and contractual choices on technical efficiency in the French urban public transport sector. The central proposition, which relies on classical contract theory arguments, is that ownership regime ...
Anne Yvrande-Billon, William Roy
core  

Analysis of proper ink management impact on overall environmental equipment efficiency for sustainability

Scientific Reports
Printing as a process itself generates many environmental concerns. The paper addresses ink management in terms of environmental issues in the label printing industry, focusing on its environmental implications.
Krzysztof Krystosiak, Aldona Kluczek, Wojciech Werpachowski   +2 more
doaj   +1 more source

High power surface emitting terahertz laser with hybrid second- and fourth-order Bragg gratings

Nature Communications, 2018
Proper design of the gratings can enhance the efficiency of distributed-feedback and quantum cascade lasers. Here, Jin et al. use a hybrid grating system that superposes second- and fourth-order Bragg gratings and achieve high radiative efficiency and a ...
Yuan Jin, Liang Gao, Ji Chen, Chongzhao Wu, John L. Reno, Sushil Kumar   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Proper Efficiency Conditions and Duality Models for Constrained Multiobjective Variational Problems Containing Arbitrary Norms [PDF]

, 1995
Necessary and sufficient proper efficiency conditions and eight duality models are presented far two classes of constrained multiobjective variational problems containing arbitrary norms and square roots of positive semidefinite quadratic ...
Zalmai, G.J.
core   +1 more source

ReviewRecent developments on applying acoustic waves for efficiency improvements of different thermofluids systems

International Journal of Thermofluids
This review classified recent works using proper acoustic waves to develop more efficient thermofluids systems for different industrial equipment such as swirl combustor, jet in crossflow, gas flare, different types of heat exchangers, cooling mechanism,
Omid Ali Zargar, Anthony Xavier Andrade, Shih-Cheng Hu, Yang-Cheng Shih, Graham Leggett   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Key technology of forming big spiral teeth shafts by fixed cross rolling

工程科学学报, 2016
Compared with traditional machining processes,the plastic forming of big spiral teeth shafts has obvious advantage of high production efficiency and material utilization,but the forming of proper tooth graduation is difficult.
YANG Guang, ZHANG Kang-sheng, HU Zheng-huan   +2 more
doaj   +1 more source