Results 31 to 40 of about 202,120 (260)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Tectonophysics map of discontinuous deformation of Rybnik region
In this paper, a Tectonophysics map of Rybnik region is presented which is based on the method of determining the direction of the trajectory of the principal stresses in the rock mass and axis orientation of these stresses.
Głogowska Magdalena, Warzecha Robert
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
A note on pseudoconvexity and proper holomorphic mappings [PDF]
In this paper we discuss some connections between proper holomorphic mappings between domains in C
Lin, E. B., Wong, B.
openaire +2 more sources
Image Quality and Quantitative Accuracy of Small Animal PET Images: Role of Physical Effects Correction and Reconstruction Algorithm [PDF]
Positron emission tomography (PET) provides important metabolic information about tracer kinetics. Photon attenuation, scattered radiation, spatial resolution limitation and reconstruction algorithm parameters are variables that influence image quality ...
Magdy Khalil
doaj +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A criterion for a proper rational map to be equivalent to a proper polynomial map
In this paper, we give an explicit criterion when a rational holomorphic map between balls is equivalent to a polynomial holomorphic map. Making use of this criterion, we show that any proper rational holomorphic map from B^2 into B^N of degree two is equivalent to a polynomial holomorphic map; we also construct rational holomorphic maps of degree 3 ...
Huang, Xiaojun, Ji, Shanyu, Zhang, Yuan
openaire +2 more sources
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source

