Results 41 to 50 of about 219,230 (257)
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Polska eponimia biblijna: Sodoma. Od urbonimu starożytnego miasta do sodomawirusa
Stylistyka, 2020 Sodom (in Polish: Sodoma) does not exist. Although this Palestinian town has been known since prehistoric times and it is mentioned in the Bible, there is no archaeological proof which would confirm its location. In 2011, the name Sodoma was removed from
Radosław Marcinkiewicz
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Proper name as an object of semiotic research
Sign Systems Studies, 2011 The present article is divided into two parts. Its theoretical introductory part takes under scrutiny how proper name has been previously dealt with in linguistics, philosophy and semiotics.
Ülle Pärli
doaj +1 more source
The Specifics of Functioning of the Personal Proper Name
Известия Южного федерального университета: Филологические науки, 2020 The article researches the specifics of how personal proper names function in the Russian and the Chinese paroemia genres. Proverbs and sayings are traditionally considered paroemia because they represent a collective evaluation of various situations of ...
Wan Yi
doaj +1 more source
Cognitive Strategies of Self-naming Among Schoolchildren (Gender Aspect) [PDF]
Вопросы ономастики, 2019 Proper name is a key means of self-presentation on the Internet. The features of Internet behavior peculiar to Generation Z have become a popular object of research, but the ways that the anonymized oral-written digital discourse impacts everyday school ...
Antonina P. Lipatova
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source