Results 41 to 50 of about 110,033 (259)

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

On classifiers and proper names

open access: yesBucharest Working Papers in Linguistics, 2007
The paper discusses the functional structure of proper names (PNs) in relation to descriptive PNs, verbs of naming, and non-literal uses of PNs. We propose that the functional structure of PNs includes not only a D [+def, j, +Person], but also a ...
Alexandra Cornilescu
doaj  

Toponyms as a separate category of onomastic lexis

open access: yesЗаписки з романо-германської філології, 2017
The present article discusses the toponymic lexis as a kind of proper names, it massively determines the structural, functional and semantic parameters of the lexis.
Є. М. Музя
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

What’s Behind a Name? Origins and Meaning of Some of the Recurrent Characters in Terry Pratchett’s Discworld

open access: yesELOPE, 2020
Nominative symbolism in fantasy is a tool to attribute certain traits to literary characters and thus to convey meaning which enriches the readers’ comprehension of the fictitious personality.
Yana Manova-Georgieva
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Proper Names as Rigid Designators

open access: yesRUDN Journal of Philosophy, 2016
The article focuses on the critical analysis of the concept of proper names as rigid designators. The arguments in favor of the theory of meaning for ordinary proper names and its problems are considered.
A Z Chernyak
doaj  

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