Results 61 to 70 of about 110,033 (259)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Krevinian Toponyms — a Review of Etymologies Presented by Dziļļeja and Other Researchers [PDF]
Linguistica UralicaLatvian proper name etymologies presented in earlier research by KÄrlis Dziļļeja, Gina ViegliÅa-Valliete, and Ilga Jansone are scrutinized here to determine whether they are Krevinian.
Simonas Noreikis
doaj +1 more source
Proper-name identification [PDF]
Speech Prosody 2012, 2012 van de Weijer, Joost +2 more
openaire +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
On Quasi-Proper Names in Japanese
Annali di Ca’ Foscari: Serie OccidentaleIn reply to Alessandro Capone’s paper entitled “On quasi-proper names”, I provide relevant data in Japanese and discuss the properties and status of quasi-names from a cross-linguistic perspective.
Mizuta, Yoko
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Kripke’s Critique of Descriptivism Revisited [PDF]
Princípios, 2010 This paper has two purposes: the first is to critically examine Kripke’s well-known arguments against Descriptivism and suggest that they are not as decisive as many have thought; the second is to argue that proper names do encode descriptive information
Pierre Baumann
doaj
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Proper Names in the Polish Global Reality
Names, 2010 The paper presents the most recent names, particularly those related to cities and towns (especially names of buildings, streets, factories, and shops) against the background of current globalization processes that assume various forms of unification or ...
Małgorzata Rutkiewicz-Hanczewska
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source