Results 131 to 140 of about 8,906,865 (345)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Hypergravity-exacerbated cracking in high-speed rotating 7075 aluminum blades

open access: yesJournal of Materials Research and Technology
On Earth, high-speed rotating blades and rotors experience hypergravity, which is mainly derived from centrifugal force. Aluminum alloys are widely used in high-speed rotating machines.
Yilin Jiao   +6 more
doaj   +1 more source

Properties of fixed point spaces [PDF]

open access: bronze, 1959
E. H. Connell
openalex   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

On Tragedy of Commons, State Sovereignty and BBNJ Treaty: Reconnoitring for Harmony

open access: yesLex Portus
Garrett Hardin’s ‘Tragedy of the Commons’ may be almost half a century old. But the centrality of the theory is still relevant for the environmental challenges associated to the management of global commons.
Arindam Basu, Sharda Mandal, Ananya Das
doaj   +1 more source

Anticompetitive effect of drug name trademark registration: lessons from China

open access: yesHumanities & Social Sciences Communications
The Chinese Trademark Law does not entirely exclude the possibility of generic names being registered as trademarks, which is inconsistent with the international standards.
Jun Shen, Xiaoting Song
doaj   +1 more source

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