Results 171 to 180 of about 1,621,321 (302)

The real option value of multistage agricultural research for development. [PDF]

PLoS One
Schiek B.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Economic Impact of Asbestos in Colombia: Estimation of the Direct and Societal Costs of Lung Cancer and Mesothelioma in 2022. [PDF]

Int J Environ Res Public Health
Villamizar G, Driscoll T, McArdle S, Frank A.   +3 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Perpetual Futures for Stocks: The SpaceX Pre-IPO Market. [PDF]

Entropy (Basel)
Gupta A, Polson NG.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Economic benefits of aquatic invasive species management in freshwater systems: A contingent valuation study. [PDF]

PLoS One
Puri R, Levers LR, Pradhananga AK.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Entropy-Based Patent Valuation: Decoding "Costly Signals" in the Food Industry via a Robust Entropy-TOPSIS Framework. [PDF]

Entropy (Basel)
Li X, Liu W, Liang X, Zhou A.
europepmc   +1 more source

Valuing Certain Personal Property, Vehicles and Watercraft / presented by Roger Hamm, Division of Property Valuation, Kansas Department of Revenue.

"March 18, 2024." Testimony before the Kansas Legislature, House Committee on Taxation, presented by Roger Hamm, Division of Property Valuation, Kansas Department of Revenue.Testimony "to provide requested information on the valuing of certain types of ...
Hamm, Roger L. (Roger Lee).
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