Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast [PDF]
, 2013 Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing organisms. Meiotic recombination is initiated by the scheduled formation of genome-wide DNA double-strand breaks (DSBs).
AJ MacQueen +40 more
core +12 more sources
Shock and Vibration, 2021 In order to reveal the influence of prophase stress levels on the fatigue damage characteristics of granite, uniaxial fatigue tests of granite with different prophase stress levels were carried out on the basis of the MTS 815.04 rock mechanics test ...
Tianzuo Wang +4 more
doaj +1 more source
Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis. [PDF]
BioessaysThe synaptonemal complex (SC) is a conserved protein structure that assembles between homologous chromosomes during meiosis. Here, we review pathways promoting homologous synapsis across model organisms, examining coordination with homolog pairing and recombination, spatiotemporal regulation of SC assembly, and the conserved molecular modules coupling ...
Gold AL, Kim Y.
europepmc +2 more sources
Cell Cycle-Dependent Dynamics of the Golgi-Centrosome Association in Motile Cells
Cells, 2020 Here, we characterize spatial distribution of the Golgi complex in human cells. In contrast to the prevailing view that the Golgi compactly surrounds the centrosome throughout interphase, we observe characteristic differences in the morphology of Golgi ...
Keyada Frye +6 more
doaj +1 more source
Active diffusion in oocytes nonspecifically centers large objects during prophase I and meiosis I
Journal of Cell Biology, 2020 Nucleus centering in mouse oocytes depends on a gradient of actin-positive vesicle persistence. Modeling coupled to 3D simulations and experimental testing of predictions coming from the simulations demonstrate that this gradient nonspecifically centers ...
A. Colin +10 more
semanticscholar +1 more source
The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance. [PDF]
, 2013 For most organisms, chromosome segregation during meiosis relies on deliberate induction of DNA double-strand breaks (DSBs) and repair of a subset of these DSBs as inter-homolog crossovers (COs).
Dernburg, Abby +6 more
core +6 more sources
Actomyosin-dependent cortical dynamics contributes to the prophase force-balance in the early Drosophila embryo. [PDF]
PLoS ONE, 2011 The assembly of the Drosophila embryo mitotic spindle during prophase depends upon a balance of outward forces generated by cortical dynein and inward forces generated by kinesin-14 and nuclear elasticity. Myosin II is known to contribute to the dynamics
Patrizia Sommi +3 more
doaj +1 more source
Meiotic chromosome dynamics and double strand break formation in reptiles
Frontiers in Cell and Developmental Biology, 2022 During meiotic prophase I, tightly regulated processes take place, from pairing and synapsis of homologous chromosomes to recombination, which are essential for the generation of genetically variable haploid gametes.
Laia Marín-Gual +11 more
doaj +1 more source
PLoS Genetics, 2020 During meiotic prophase, sister chromatids are organized into axial element (AE), which underlies the structural framework for the meiotic events such as meiotic recombination and homolog synapsis.
Y. Fujiwara +11 more
semanticscholar +1 more source
Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one [PDF]
, 2007 Background The vast majority of oocytes formed in the fetal ovary do not survive beyond birth. Possible reasons for their loss include the elimination of non-viable genetic constitutions arising through meiosis, however, the ...
Ghafari , Fataneh +2 more
core +4 more sources