Results 51 to 60 of about 2,060 (125)

An Alternatively Spliced Bifunctional Localization Signal Reprograms Human Shugoshin 1 to Protect Centrosomal Instead of Centromeric Cohesin

Cell Reports, 2015
Separation of human sister chromatids involves the removal of DNA embracing cohesin ring complexes. Ring opening occurs by prophase-pathway-dependent phosphorylation and separase-mediated cleavage, with the former being antagonized at centromeres by Sgo1-
Lisa Mohr, Johannes Buheitel, Laura Schöckel, Dorothea Karalus, Bernd Mayer, Olaf Stemmann   +5 more
doaj   +1 more source

Lysine demethylase 4A is a centrosome‐associated protein required for centrosome integrity and genomic stability

The FEBS Journal, EarlyView.
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury, Xiaoli Wang, Richard I. Han, Manga Motrapu, Ashley G. Boice, Yuya Nakatani, Sofia Vargas‐Hernandez, Julia F. Love, Claude Chew, Sandra L. Grimm, Dereck Mezquita, Frank M. Mason, Elisabeth D. Martinez, Cristian Coarfa, Cheryl L. Walker, Anna‐Karin Gustavsson, Ruhee Dere   +16 more
wiley   +1 more source

Centripetal nuclear shape fluctuations associate with chromatin condensation in early prophase [PDF]

, 2023
Viola Introini, Gururaj Rao Kidiyoor, Giancarlo Porcella, Pietro Cicuta, Marco Cosentino Lagomarsino   +4 more
openalex   +1 more source

DNA damage in mitosis: SOD1 delays anaphase onset

The FEBS Journal, EarlyView.
Mitotic cells do not exhibit a DNA damage checkpoint delay and do not repair DNA double strand breaks (DSBs) until the next cell cycle. Instead, DSBs can delay anaphase through the mitotic spindle checkpoint, by an incompletely understood mechanism. Li et al.
George Zachos
wiley   +1 more source

The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in Caenorhabditis elegans

eLife
Meiotic crossover recombination is essential for both accurate chromosome segregation and the generation of new haplotypes for natural selection to act upon. This requirement is known as crossover assurance and is one example of crossover control.
Bhumil Patel, Maryke Grobler, Alberto Herrera, Elias Logari, Valery Ortiz, Needhi Bhalla   +5 more
doaj   +1 more source

Dual pathway spindle assembly increases both the speed and the fidelity of mitosis

Biology Open, 2011
Summary Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Kuniyoshi Kaseda, Andrew D. McAinsh, Robert A. Cross   +2 more
doaj   +1 more source

New insights into the putative XX/XY sex chromosomal system in blue‐eyed red‐fin pleco Hypostomus soniae (Siluriformes, Loricariidae)

Journal of Fish Biology, EarlyView.
Abstract Blue‐eyed red‐fin pleco Hypostomus soniae (family Loricariidae) presented a putative sex system XX/XY in early stage. Aiming to explore the inter‐populational karyotypic variation and proposed emergence of the XX/XY system, we studied 13 H. soniae individuals (6 males, 7 females) from the Tapajós River.
Luan Aércio Melo Maciel, Renata Coelho Rodrigues Noronha, Bruno Rafael Ribeiro de Almeida, Manoella Gemaque Cavalcante, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka, Luís Reginaldo R. Rodrigues   +6 more
wiley   +1 more source

Aggregations of organelles in meiotic cells of higher plants

Acta Societatis Botanicorum Poloniae, 2014
During early prophase I in microsporocytes and sporocytes of various plants all mitochondria and plastids aggregate in a group, where some plastids seem to undergo division. This group desintegrates by middle prophase I.
Bohdan Rodkiewicz, Ewa Duda
doaj   +1 more source

Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica

New Phytologist, EarlyView.
Summary Polyploidization, followed by genome downsizing, is a recurrent evolutionary cycle that dramatically reshapes genome structure. Newly formed polyploids must quickly adjust their cell division machinery to maintain stable chromosome inheritance, while long‐term stabilization involves rediploidization, returning the genome to a diploid‐like state.
Robin Burns, Anna Glushkevich, Aboli Kulkarni, Uliana K. Kolesnikova, Filip Kolář, Alison Dawn Scott, Polina Yu. Novikova   +6 more
wiley   +1 more source

Research Focus at Different Stages of Urban Rail Transit Prophase Works in the New Era

Chengshi guidao jiaotong yanjiu
[Objective] In the future, China′s urban development will shift from construction-orientation to governance-orientation. As an important part of the Chinese-style modern social governance system, urban planning is an important lever and tool to improve ...
Zichang LIU
doaj   +1 more source